April 13, 2024 - The Bountiful Benefits of Butryate!

"You have more power than you know!"

Butyrate is created in our guts by prebiotics.

Butyrate boasts very many health benefits, and when it comes to weight loss and control has been coined:

"Nature's Ozembic"

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What is butyrate? The body uses fat for energy. Some fats necessary for human health are created by the body, while others are found in the food we eat (“essential” fats). Butyrate is created by bacteria in the colon as a by-product of the breakdown of carbohydrates and fermentation of fiber from food. (1) It is important for digestion and critical for colon health. But butyrate benefits are much more extensive and influential than that.

The following types of dietary fiber produce short-chain fatty acids:

• Inulin from artichokes, garlic, leeks, onions, and asparagus.
• Fructo-oligosaccharides found in fruits and vegetables, including bananas, onions, garlic, and asparagus.
• Resistant starch in green bananas and brown rice.
• Pectin: apples, apricots, carrots, and oranges.
• Arabinoxylan, a by-product of wheat flour and other cereal grains.
• Arabinogalactan from carrots, corn, wheat, tomatoes, pears, and radishes.
• 

When we think of the word “bacteria”, it often comes in a negative context, as some bacteria are responsible for illness. However, our bodies are home to gazillions of bacteria, most of which are necessary for our survival. Butyrate is an example of why this is so.

The bacteria that produce butyrate include Firmicutes, which thrives in acidic environments. Butyrates can also be found in animal products, such as butter and other dairy products (2).

Stimulation of GLP-1 Secreting Cells:

Butyrate directly stimulates L-cells in the gut lining to secrete GLP-1. L-cells are enteroendocrine cells that produce GLP-1 among other hormones.

Butyrate increases the activity of these cells, thereby enhancing the production of GLP-1

Healthy Appetite Goals:

By influencing the production of hormones like GLP-1 and peptide YY (PYY), butyrate can help regulate appetite and satiety, potentially leading to reduced food intake

GPR41/43 Activation:

Butyrate acts as a ligand for G-protein-coupled receptors (GPCRs) expressed on enteroendocrine L-cells. Activation of these receptors by butyrate can trigger signaling pathways that lead to GLP-1 secretion.

"GLP-1 agonists work by mimicking the effects of a hormone called GLP-1, which is produced naturally in the body in response to food consumption. This hormone is involved in regulating insulin secretion, feelings related to hunger and the emptying of the stomach. GLP-1 agonists bind to GLP-1 receptors in the body, thereby resulting in the same effects.

“By activating receptors in the pancreas, [GLP-1 agonists are] able to regulate insulin and control blood sugar,” explains Spencer Nadolsky, D.O., an obesity specialist physician based in Portage, Michigan and medical director of Sequence, an online weight loss program. “But they also activate receptors in the brain to curb appetite and in the gut to slow stomach emptying.”

A GLP-1 agonist can impact satiety and cravings to support weight loss, he adds. “It helps you eat fewer calories by making you feel more satisfied with decreased cravings.” LEARN MORE