UCHL1: Not just a neuronal biomarker

Dear Researcher,


UCHL1 is the part of the ubiquitin family of proteases and processing enzymes and is considered one of the most highly expressed proteins in neurons. It plays many important roles inside and outside of neurobiology, and it has been the subject of several research studies. More recently, UCLH1 is increasingly associated as a biomarker in many diseases and metabolic conditions (see graphic above).

Biosensis offers UCHL1 antibodies for your research: a mouse monoclonal and rabbit or chicken-hosted polyclonal antibody. All these antibodies are applicable for ICC, IHC and WB analyses. 

View our UCHL1 antibodies

ICC analysis of UCHL1 expression in rat neuron-glial cell culture with chicken antibody to UCHL1 

(C-1406, red) and co-stained with a mouse antibody to vimentin (green)

ICC analysis of UCHL1 expression in rat with mouse antibody to UCHL1 (M-1407, green) and co-stained with rabbit-anti-FOx3/NeuN

(R-3700, red)

 ICC analysis of SH-SY5Y cells for UCHL1 expression with rabbit antibody to UCHL1 (R-1408, green)and co-stained with mouse antibody  to fibrillarin (red)

Expressed in not just the brain but also in the heart


Wu et al. (2022) provided the first genetic evidence for the expression of UCHL1 protein in cardiomyocytes, which is confirmed by immunofluorescence (IF) staining.


The image (right) shows the IF staining of UCHL1 (red) and sarcomeric alpha-actin (green) in the mouse's heart (Front Cardiovasc Med. 2022; 9: 866901, figure 2).


For easy online ordering, head to our new website, or contact our friendly sales team at sales@biosensis.com.


For more information about our products, including new UCHL1 ELISA kit coming soon, email biospeak@biosensis.com.


Best wishes for your research,



The Biosensis Team



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