In April we celebrated our 10^th International HP Technology Workshop that featured 39 speakers from 23 institutions across the US, Europe, & Asia, hands-on demonstrations and discussions of new technologies, methods, and software. Featured in this newsletter, we highlight the video presentations of the workshops that are released for viewing.

Also, included in this newsletter is the 2023 overview of all human studies performed through 2023 from 14 sites that are conducting patient and volunteer HP C-13 research.

A big thanks to our sponsors who participated in the workshop. The collaboration and technology development discussed at the workshop was both inspiring and informative. We look forward to continued collaborations.

Best regards,

The HMTRC team & Collaborators

The 2024 Workshop had a record-breaking attendance with 246 participants from 44 institutions that included personnel from academia, industry, and government organizations. International representatives came from China, Denmark, England, Germany, Israel, Japan, Singapore, South Korea, Spain, and Taiwan. 

Many thanks to the Gold Sponsors of the event, Bruker BioSpin, GE Healthcare, MilliporeSigma Isotec Stable Isotopes Division, and NVision Imaging Technologies.

The available recorded presentation links are listed below.

Hyperpolarized Metabolic MRI Imaging:

a Record 250 new subjects in 2023!

By Jean-Luc Vanderheyden, PhD, JLVMI Consulting LLC

As depicted in the graph, the progression of clinical studies over the last five years shows, 14 sites cumulated over 1,650 studies on 1,112 patients till the end of December 2023. This corresponds to an increase of 249 subjects and 381 studies for the year, a new milestone, demonstrating the continued interest in exploring the capabilities of metabolic MRI imaging with hyperpolarized C-13 Pyruvate towards unmatched clinical applications.

As can be seen from the attached table, many of these studies represented multiple injections, with 40% of subjects receiving at least a second dose, thus allowing test/retest or follow up of responses to therapy. This also attests to the high safety profile of the formulation, composed of 250 mM pyruvate with a 3-5 uM EPA limit, typically delivered at a rate of 0.43 mL/kg body weight. Only self-reported mild side effects associated with the injection and no moderate or severe adverse events even after multiple administrations to the same subject were reported. 

Like in previous years, on average, three out of 10 studies involved volunteers. The applications have remained focused on cancer patients, with prostate, brain and other solid tumors, but cardiology (with about 22% of all studies) continued to gain high interest.

Also presented at the workshop, major milestones were accomplished in the co-injecting of hyperpolarized C-13 Pyruvate and C-13 urea and additional probes have entered clinical evaluations facilitated by Multi-Probe Quality Control (MPQC) units that showed flexibility at an astonishing speed with the partial release of a drug product in a matter of seconds!!

Over 100 publications describing the results and clinical implications of hyperpolarized C-13 MRI were authored and released to date. A special mention to the review publication of Peder Larson et al in Magnetic Resonance in Medicine titled “Current methods for hyperpolarized [1-¹³C] pyruvate MRI human studies” that provided a consensus view. 

Congratulations to all those involved at the 14 sites, and particularly Cambridge, UT Southwestern and UCSF for having exceed the 100-subjects milestone!! 

Visit the HMTRC Website Resources Page for

tools & tutorials to advance your research and training!

Now available! 28+ presentations to re-watch or watch for the first time! Watch to get updates from the center, or see what

others have been doing in their HP ¹³C preclinical and clinical research.

Photo Credits 2024 HMTRC Workshop: fallfoto, Elizabeth Gall 2024

New Seminar Presentations

Visit or re-visit some recent video presentations on advances in HP ¹³C MRI Research for Clinical Translation.

Recent journal articles supported by the center

to inspire & drive your basic and clinical research

Upcoming Seminar: Tuesday June 11th, 3pm PT

Zoom ID: 897 4922 2365, Passcode: 758802

Call for Seminar Presenters

We are currently looking for presenters for the International HP C-13 MRI Seminar in September & October 2024. Present new findings, publications, or other work in preclinical and human research. Presentations are 25 minutes with a 5-minute Q&A. Email us at hyperpolarizedmri@ucsf.edu.

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