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"Sleep apnea, hypoxia, and late-onset epilepsy: the Atherosclerosis Risk in Communities study," Christopher M Carosella, Rebecca F Gottesman, Anna Kucharska-Newton, Pamela L Lutsey, Adam P Spira, Naresh Punjabi, Andrea L C Schneider, Kelsie M Full, Emily L Johnson
Abstract: Sleep apnea is associated with unexplained epilepsy in older adults in small studies. We sought to determine the relationship between sleep apnea and additional sleep characteristics and late-onset epilepsy, adjusting for comorbidities, using data from the large, prospective Atherosclerosis Risk in Communities (ARIC) Study cohort.
"Prevalence and Factors Associated with Subjective Memory Complaint in a Semi-Rural Community in Chile," Ximena Oyarzún-González, Erin L Abner, Pablo Toro, Catterina Ferreccio
Abstract: Subjective memory complaints (SMC) are commonly studied in older adults and have been identified as potentially prodromal to dementia and Alzheimer's disease. Studies among younger adults from South America are lacking.
"Drugs involved in Kentucky drug poisoning deaths and relation with antecedent controlled substance prescription dispensing," Patricia R Freeman, Jana McAninch, Nabarun Dasgupta, Douglas R Oyler, Krassimir Slavov, Candice Collins, Sarah Hargrove, Edward Freeman, Dustin Miracle, Svetla Slavova
Abstract: The shift from prescription to illicit drugs involved in drug poisoning deaths raises questions about the current utility of prescription drug monitoring program (PDMP) data to inform drug poisoning (overdose) prevention efforts. In this study, we describe relations between specific drugs involved in Kentucky drug poisoning deaths and antecedent controlled substance (CS) dispensing.
"Atorvastatin rescues hyperhomocysteinemia-induced cognitive deficits and neuroinflammatory gene changes," Erica M Weekman, Sherika N Johnson, Colin B Rogers, Tiffany L Sudduth, Kevin Xie, Qi Qiao, David W Fardo, Teodoro Bottiglieri, Donna M Wilcock
Abstract: Epidemiological data suggests statins could reduce the risk of dementia, and more specifically, Alzheimer's disease (AD). Pre-clinical data suggests statins reduce the risk of dementia through their pleiotropic effects rather than their cholesterol lowering effects. While AD is a leading cause of dementia, it is frequently found co-morbidly with cerebral small vessel disease and other vascular contributions to cognitive impairment and dementia (VCID), which are another leading cause of dementia. In this study, we determined if atorvastatin ameliorated hyperhomocysteinemia (HHcy)-induced VCID.
"Manipulation of components of the renin angiotensin system in renal proximal tubules fails to alter atherosclerosis in hypercholesterolemic mice," Masayoshi Kukida, Naofumi Amioka, Dien Ye, Hui Chen, Jessica J Moorleghen 1, Ching-Ling Liang, Deborah A Howatt, Yuriko Katsumata, Motoko Yanagita, Hisashi Sawada, Alan Daugherty, Hong S Lu
Abstract: Whole body manipulation of the renin-angiotensin system (RAS) consistently exerts profound effects on experimental atherosclerosis development. A deficit in the literature has been a lack of attention to the effects of sex. Also, based on data with gene-deleted mice, the site of RAS activity that influences lesion formation is at an unknown distant location. Since angiotensin (AngII) concentrations are high in kidney and the major components of the RAS are present in renal proximal tubule cells (PTCs), this study evaluated the role of the RAS in PTCs in atherosclerosis development.
"Impacts of intergenerational substance use and trauma among black women involved in the criminal justice system: A longitudinal analysis," Abenaa A Jones, Meredith S Duncan, Amaya Perez-Brumer, Christian M Connell, William B Burrows, Carrie B Oser
Abstract: Intergenerational substance use and trauma disproportionately impact racialized women. Yet, how these factors impact outcomes in women involved in the criminal justice system is understudied.
"Effectiveness of a Bystander Intervention Program to Increase Bystander Behaviors Across Latent Risk Groups of High Schoolers," Annelise Mennicke, Heather M Bush, Candace J Brancato, Gabrielle Haley, Erin Meehan, Ann L Coker
Abstract: Bystander intervention programs have established efficacy to increase bystander behaviors to prevent interpersonal violence (IPV). Little research has investigated intervention efficacy among latent risk classes among high school students. Data from a five-year randomized control trial were used to conduct multigroup path analyses to assess the association between type of training received and bystander outcomes moderated by risk groups identified via latent profile analysis (LPA).
"Spousal Cognitive Status and Risk for Declining Cognitive Function and Dementia: The Atherosclerosis Risk in Communities Study," Mark Lee, Ryan T Demmer, Anna Kucharska-Newton, Beverly Gwen Windham, Priya Palta, Tetyana Shippee, Pamela L Lutsey
Abstract: We investigated the relationship between the cognitive status of participants' spouses and participants' own cognitive outcomes, controlling for mid-life factors.
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