Healthcare policies of the current administration, along with a hostile social climate, may seriously harm sexual and gender minority (SGM) patients, particularly SGM patients of color who often have worse health outcomes than the general population. To address this challenge and ensure quality care for SGM patients, Judy Tan and colleagues discuss key policy issues affecting the health of SGM patients of color. Questions are posed to clinicians to engage them in self-examination, skills development, political action and advocacy. Additionally, researchers offer concrete, actionable steps to advocate for SGM patients of color in patient care, healthcare organizations, medical education, research, and public policy.