Evolving Experimental Techniques for Structure Based Drug Design | |
Image Source: Cerione, et al. (2022). Evolving Experimental Techniques for Structure-Based Drug Design J. Phys. Chem. B (2022), 126, 35, 6599-6607 doi: https://doi.org/10.1021/acs.jpcb.2c04344 | |
In a paper at The Journal of Physical Chemistry B, Richard A. Cerione et al. "highlight recent advances in the development of structural techniques that are capable of probing dynamic information about protein targets," 1 which are important in structure-based drug design (SBDD).
The techniques discussed are X-ray crystallography including serial room-temperature crystallography, cryogenic electron microscopy (cryoEM) and small-angle X-ray scattering (SAXS).
1. Evolving Experimental Techniques for Structure-Based Drug Design
Cody Aplin, Shawn K. Milano, Kara A. Zielinski, Lois Pollack, and Richard A. Cerione
The Journal of Physical Chemistry B 2022 126 (35), 6599-6607
DOI: 10.1021/acs.jpcb.2c04344
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APS Upgrade Shutdown - Alternative Beamlines | | |
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Are you a user of the APS (Advanced Photon Source) beamlines? As you know the beamlines at APS will be shutdown for an entire year to make way for upgrades. We can help you find an alternative beamline for your research as well as get you equipped to conduct your research there. Reach out to us and let us help you get up and running at an alternative beamline. | |
MiTeGen Generation 2.0 Cryo-EM Pucks | | |
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Have you tried our pucks for cryo-EM yet? Our generation 2.0 cryo-EM pucks allow you to organize, track, and ship your samples on grids for single particle analysis and other Cryogenic Electron Microscopy applications.
Our pucks have many ease of use features such as 12 well locations per puck, a clear affixed lid that rotates for grid box insertion, they accept all round cryo-EM grid storage boxes and much more!
And, our pucks are accepted and in use at many cryo-EM facilities worldwide.
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Marilyn M. Olmstead Inorganic Chemistry Research Fund | | |
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The Marilyn M. Olmstead Inorganic Chemistry Graduate Research Fund needs $20,000 to achieve its funding goal. Fortunately, a generous donor has recently pledged to match all gifts dollar for dollar up to a total of $30,000 through December 31, 2022. So, now is a great opportunity to make a donation. | |
Protein Crystallography Starter Kit | | |
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Did you know we offer a Protein Crystallography Starter Kit which is an ideal training tool for new students and technicians as well as for workshops and summer schools?
It has everything you need to mount and collect X-ray data from your crystals at both room temperature and at cryo temperatures and can be customized to your specific needs.
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At MiTeGen, we sponsor numerous events, conferences, workshops and symposiums throughout the year. These events include fields such as structural biology, crystallography, cryo-EM, beamline research and more. We believe in supporting researchers and our industry. Listed below are two upcoming events you might find interesting. | |
The CCP4/BGU workshop on data collection and structure determination is Feb. 26th to March 1st. Designed for students, postdocs and/or researchers with some previous expertise in crystallography who need a deeper insight into the most advanced structural biology techniques to carry out their research projects. We are sponsoring the workshop. | |  |
Hot Topics in Contemporary Crystallography 5 (HTCC5) workshop is April 16th to the 21st. It brings together leading experts and motivated young scientists in crystallography and related fields as “students” and who are interested in acquiring new knowledge on the cutting-edge methods in structural science and exploring ways to apply them in their ongoing research. We are sponsoring this workshop. | | |
Looking For More Events, Workshops and Conferences | | |
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If you are looking for more events visit our events page. It lists conferences, workshops, symposiums, user meetings and more.
Topics include structural biology, material science, crystallography, cryo-EM, beamline research and more.
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Industry Resources and News | |
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Here is a small selection of industry resources and news for your browsing.
- Interesting reading from Wiley Online Library, Chemical Crystallography before X-ray Diffraction - Learn More
- Book review from the IUCr, Secret of Life: Rosalind Franklin, James Watson, Francis Crick, and the discovery of DNA's Double Helix - Learn More
- Beamline for Schools, an international physics competition for high school students, is now accepting application. Teams of high-school students can propose a scientific experiment that they want to perform at a particle accelerator - Learn More
- ThermoFisher Scientific has a Electron Microscopy Funding Support Center that gives you access to technical content, resources, and proposal writing tools to help with cryo-EM grant funding needs - Learn More
- ESRF, The European Synchrotron in Grenoble France is implementing a New Access Mode which groups together researchers using similar techniques or working on scientific topics addressing significant societal challenges - Learn More
- Diamond Light Source offers an undergraduate summer placement which will involve testing new tools and putting the new VMXm beamline through its paces - Learn More
- HZB (BESSY II) is now accepting applications for its International Summer Student Program (ISSP). International students will have the chance to work on their own research project in close cooperation with HZB scientists - Learn More
- National Cryo-Electron Microscopy Facility at Frederick National Laboratory is offering free access to prospective users who provide a statement that their project is relevant to cancer research - Learn More
- CryoCloud, a cloud platform for cryo-EM data analysis is now live and is looking for a small circle of initial testers. If you are interested in using their cloud platform for your cryoEM data analysis, send them an email at: hi@cryocloud.io - Learn More
- CryoSPARC guide to collecting cryo-EM data externally and to continue processing in your home installation is now available - Learn More
- Kihara Laboratory has released the DAQ-Score Database which is a deep-learning-based score that quantifies residue-wise local quality for protein models from cryo-electron microscopy (cryo-EM) maps - Learn More
- CCDC Cambridge has a short guide on accessing information stored within a CIF including how to read, edit and extract information - Learn More
- ThermoFisher Scientific offers a podcast called Science With A Twist which is designed for "people who enjoy exploring how science impacts our daily lives" - Learn More
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Searching for a new job? Interested in knowing what positions labs and facilities are offering? Then visit our jobs board on which we list recent industry job offerings.
And remember, if you have an industry relevant job, we are happy to list it on our jobs board.
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