February 2020 The Science Spotlight newsletter features publications from Brigham researchers in high-impact journals and funding updates from the prior month. In January there were: 37 papers led by Brigham researchers published in top-tier journals 1 research brief 9 press releases 21 tweets about new research 50 awards with $14,050,864 in new grants

Molecular signatures of aneuploidy-driven adaptive evolution. Kaya A, Mariotti M, Tyshkovskiy A, Zhou X, Hulke ML, [et al.] Gladyshev VN. Nat Commun . 2020 Jan 30;11(1):588. doi: 10.1038/s41467-019-13669- 2.

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Immunological Fingerprints of Controllers Developing Neutralizing HIV-1 Antibodies. Martin-Gayo E, Gao C, Chen HR, Ouyang Z, Kim D, [et al.] Yu XG. Cell Rep . 2020 Jan 28;30(4):984-996.e4. doi: 10.1016/j.celrep.2019.12.087.

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Soluble Urokinase Receptor and Acute Kidney Injury. Hayek SS, Leaf DE, Samman Tahhan A, Raad M, Sharma S, [et al.] Reiser J. N Engl J Med . 2020 Jan 30;382(5):416-426. doi: 10.1056/NEJMoa1911481.

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The Neglected Hospital - The District Hospital's Central Role in Global Health Care Delivery. Rajbhandari R, McMahon DE, Rhatigan JJ, Farmer PE. N Engl J Med . 2020 Jan 30;382(5):397-400. doi: 10.1056/NEJMp1911298.

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Orchestration of human macrophage NLRP3 inflammasome activation by  Staphylococcus aureus  extracellular vesicles. Wang X, Eagen WJ, Lee JC. Proc Natl Acad Sci U S A . 2020 Feb 11;117(6):3174-3184. doi: 10.1073/pnas.1915829117

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Revisiting the National Institutes of Health Fair Pricing Condition: Promoting the Affordability of Drugs Developed With Government Support. Sarpatwari A, LaPidus AK, Kesselheim AS. Ann Intern Med . 2020 Jan 28. doi: 10.7326/M19-2576.

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Who Owns Sepsis? Klompas M, Osborn TM, Rhee C. Ann Intern Med . 2020 Jan 28. doi: 10.7326/M19-2966.

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Faecal microbiota transplantations and urinary tract infections - Authors' reply. Allegretti JR, Mullish BH. Lancet . 2020 Jan 25;395(10220):271. doi: 10.1016/S0140-6736(19)32978-2.

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Step-Up Therapy in Black Patients with Asthma. Reply. Wechsler ME, Ortega VE, Israel E; NHLBI AsthmaNet. N Engl J Med . 2020 Jan 23;382(4):391-392. doi: 10.1056/NEJMc1915819.

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Advancing Safety and Equity Together. Sivashanker K, Gandhi TK. N Engl J Med . 2020 Jan 23;382(4):301-303. doi: 10.1056/NEJMp1911700.

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Association of Low-Carbohydrate and Low-Fat Diets With Mortality Among US Adults. Shan Z, Guo Y, Hu FB, Liu L, Qi Q. JAMA Intern Med . 2020 Jan 21. doi: 10.1001/jamainternmed.2019.6980.

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β4GALT1 controls β1 integrin function to govern thrombopoiesis and hematopoietic stem cell homeostasis. Giannini S, Lee-Sundlov MM, Rivadeneyra L, Di Buduo CA, Burns R, [et al.] Hoffmeister KM. Nat Commun . 2020 Jan 17;11(1):356. doi: 10.1038/s41467-019-14178-y.

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Utilizing Ribose Compounds: How Bacteroides PUL It Off. García-Bayona L, Comstock LE. Cell Host Microbe . 2020 Jan 8;27(1):6-8. doi: 10.1016/j.chom.2019.12.010.

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The moral case for global mental health delivery. Patel V, Farmer PE. Lancet . 2020 Jan 11;395(10218):108-109. doi: 10.1016/S0140-6736(19)33149-6. Epub 2020 Jan 9.

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FDA Approval and Regulation of Pharmaceuticals, 1983-2018. Darrow JJ, Avorn J, Kesselheim AS. JAMA . 2020 Jan 14;323(2):164-176. doi: 10.1001/ jama .2019.20288.

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RAP80 and BRCA1 PARsylation protect chromosome integrity by preventing retention of BRCA1-B/C complexes in DNA repair foci. Vohhodina J, Toomire KJ, Petit SA, Micevic G, Kumari G, [et al.] Hu Y. Proc Natl Acad Sci U S A . 2020 Jan 28;117(4):2084-2091. doi: 10.1073/pnas.1908003117. Epub 2020 Jan 13.

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Assessing the Risk for Gout With Sodium-Glucose Cotransporter-2 Inhibitors in Patients With Type 2 Diabetes: A Population-Based Cohort Study. Fralick M, Chen SK, Patorno E, Kim SC. Ann Intern Med . 2020 Jan 14. doi: 10.7326/M19-2610.

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Incidental Imaging Findings in Clinical Trials. Oren O, Blankstein R, Bhatt DL. JAMA . 2020 Jan 13. doi: 10.1001/ jama .2019.21813. [Epub ahead of print]

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Extracting the benefits of berberine for colorectal cancer. Kwon S, Chan AT. Lancet Gastroenterol Hepatol . 2020 Jan 8. pii: S2468-1253(19)30430-3. doi: 10.1016/S2468-1253(19)30430-3. [Epub ahead of print]

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REWIND to fast forward: time to revisit stroke prevention in type 2 diabetes? Aroda V. Lancet Diabetes Endocrinol . 2020 Feb;8(2):90-92. doi: 10.1016/S2213-8587(19)30427-9. Epub 2020 Jan 7.

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Smoking cessation and weight change in relation to cardiovascular disease incidence and mortality in people with type 2 diabetes: a population-based cohort study. Liu G, Hu Y, Zong G, Pan A, Manson JE, [et al.] Sun Q. Lancet Diabetes Endocrinol . 2020 Feb;8(2):125-133. doi: 10.1016/S2213-8587(19)30413-9. Epub 2020 Jan 7.

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Microglia, Lifestyle Stress, and Neurodegeneration. Madore C, Yin Z, Leibowitz J, Butovsky O. Immunity . 2020 Jan 2. pii: S1074-7613(19)30499-6. doi: 10.1016/j.immuni.2019.12.003. [Epub ahead of print]

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In vitro characterization of the human segmentation clock. Diaz-Cuadros M, Wagner DE, Budjan C, Hubaud A, Tarazona OA, [et al.] Pourquié O. Nature . 2020 Jan 8. doi: 10.1038/s41586-019-1885-9.

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BCL9 provides multi-cellular communication properties in colorectal cancer by interacting with paraspeckle proteins. Jiang M, Kang Y, Sewastianik T, Wang J, Tanton H, [et al.] Carrasco RD. Nat Commun . 2020 Jan 7;11(1):19. doi: 10.1038/s41467-019-13842-7.

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Changes in Utilization of Generic Angiotensin Receptor Blockers Following Product Recalls in the United States. Desai RJ, Sarpatwari A, Gautam N, Lii J, Fischer MA, Gagne JJ. JAMA . 2020 Jan 7;323(1):87-89. doi: 10.1001/ jama .2019.17521.

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Connecting With Patients-The Missing Links. Sanders L, Fortin AH 6th, Schiff GD. JAMA . 2020 Jan 7;323(1):33-34. doi: 10.1001/ jama .2019.20153.

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The responsibility and potential of public health. Dhillon RS, Karan A. Lancet . 2020 Jan 4;395(10217):29. doi: 10.1016/S0140-6736(19)31911-7.

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To Treat My Patient, I Had To Understand Her Trauma. Rittenberg E. Health Aff (Millwood) . 2020 Jan;39(1):161-164. doi: 10.1377/hlthaff.2019.00422.

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Among Low-Income Adults Enrolled In Medicaid, Churning Decreased After The Affordable Care Act. Goldman AL, Sommers BD. Health Aff (Millwood) . 2020 Jan;39(1):85-93. doi: 10.1377/hlthaff.2019.00378.

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Professional Dissonance and Burnout in Primary Care: A Qualitative Study. Agarwal SD, Pabo E, Rozenblum R, Sherritt KM. JAMA Intern Med . 2020 Jan 6. doi: 10.1001/jamainternmed.2019.6326.

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Disclose and Manage Conflicts of Interest at Cancer Centers-Reply. Carr D, Welch HG. JAMA Intern Med . 2020 Jan 1;180(1):161-162. doi: 10.1001/jamainternmed.2019.5547.

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Changes in Quality of Care after Hospital Mergers and Acquisitions. Beaulieu ND, Dafny LS, Landon BE, Dalton JB, Kuye I, McWilliams JM. N Engl J Med . 2020 Jan 2;382(1):51-59. doi: 10.1056/NEJMsa1901383.

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Epidemiologic Signatures in Cancer. Reply. Welch HG, Kramer BS, Black WC. N Engl J Med . 2020 Jan 2;382(1):96-98. doi: 10.1056/NEJMc1914747.

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Unravelling the heterogeneity of epilepsy for optimal individualised treatment: advances in 2019. Pennell PB. Lancet Neurol . 2020 Jan;19(1):8-10. doi: 10.1016/S1474-4422(19)30430-2.

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Epithelial-specific isoforms of protein 4.1R promote adherens junction assembly in maturing epithelia. Huang SC, Liang JY, Vu LV, Yu FH, Ou AC, [et al.] Benz EJ Jr. J Biol Chem . 2020 Jan 3;295(1):191-211. doi: 10.1074/jbc.RA119.009650

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Coupling APEX labeling to imaging mass spectrometry of single organelles reveals heterogeneity in lysosomal protein turnover. Narendra DP, Guillermier C, Gyngard F, Huang X, Ward ME, Steinhauser ML. J Cell Biol . 2020 Jan 6;219(1). pii: e201901097. doi: 10.1083/jcb.201901097.

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Transcriptional Silencers in Drosophila Serve a Dual Role as Transcriptional Enhancers in Alternate Cellular Contexts. Gisselbrecht SS, Palagi A, Kurland JV, Rogers JM, Ozadam H, [et al.] Bulyk ML. Mol Cell . 2020 Jan 16;77(2):324-337.e8. doi: 10.1016/j.molcel.2019.10.004

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