January 2020 The Science Spotlight newsletter features publications from Brigham researchers in high-impact journals and funding updates from the prior month. In December there were: 17 papers led by Brigham researchers published in top-tier journals 2 research briefs 7 press releases 18 tweets about new research 32 awards and $8,052,415 awarded in new grants

Patterns of Aging Biomarkers, Mortality, and Damaging Mutations Illuminate the Beginning of Aging and Causes of Early-Life Mortality Kinzina ED, Podolskiy DI, Dmitriev SE, Gladyshev VN. Cell Rep . 2019 Dec 24;29(13):4276-4284.e3. doi: 10.1016/j.celrep.2019.11.091.

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Cardiometabolic disease costs associated with suboptimal diet in the United States: A cost analysis based on a microsimulation model. Jardim TV, Mozaffarian D, Abrahams-Gessel S, Sy S, Lee Y, [et al.] Gaziano TA. PLoS Med . 2019 Dec 17;16(12):e1002981. doi: 10.1371/journal.pmed.1002981

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A large peptidome dataset improves HLA class I epitope prediction across most of the human population. Sarkizova S, Klaeger S, Le PM, Li LW, Oliveira G, [et al.] Keskin DB. Nat Biotechnol . 2019 Dec 16. doi: 10.1038/s41587-019-0322-9.

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Hospital-Level Care at Home for Acutely Ill Adults: A Randomized Controlled Trial. Levine DM, Ouchi K, Blanchfield B, Saenz A, Burke K, [et al.] Schnipper JL. Ann Intern Med . 2019 Dec 17. doi: 10.7326/M19-0600.

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Sodium-Glucose Cotransporter-2 Inhibitors and Urinary Tract Infections. Dave CV, Schneeweiss S, Kim D, Fralick M, Patorno E. Ann Intern Med . 2019 Dec 17;171(12):944-945. doi: 10.7326/L19-0671.

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Characteristics of Americans With Primary Care and Changes Over Time, 2002-2015 Levine DM, Linder JA, Landon BE. JAMA Intern Med . 2019 Dec 16. doi: 10.1001/jamainternmed.2019.6282.

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Penicillin Allergy. Castells M, Khan DA, Phillips EJ. N Engl J Med . 2019 Dec 12;381(24):2338-2351. doi: 10.1056/NEJMra1807761.

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Machine Learning and the Cancer-Diagnosis Problem - No Gold Standard. Adamson AS, Welch HG. N Engl J Med . 2019 Dec 12;381(24):2285-2287. doi: 10.1056/NEJMp1907407.

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T cell receptor specificity drives accumulation of a reparative population of regulatory T cells within acutely injured skeletal muscle. Cho J, Kuswanto W, Benoist C, Mathis D. Proc Natl Acad Sci U S A. 2019 Dec 10. pii: 201914848. doi: 10.1073/pnas.1914848116.

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Metabolic Control of Astrocyte Pathogenic Activity via cPLA2-MAVS. Chao CC, Gutiérrez-Vázquez C, Rothhammer V, Mayo L, Wheeler MA, [et al.] Quintana FJ. Cell . 2019 Dec 12;179(7):1483-1498.e22. doi: 10.1016/j. cell .2019.11.016.

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Facing Uncertainty. Thomas C, Vleugels RA, Kwiatkowski DJ, Levy B, Loscalzo J. N Engl J Med . 2019 Dec 5;381(23):2253-2259. doi: 10.1056/NEJMcps1906037.

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Potential Medicare Savings on Inhaler Prescriptions Through the Use of Negotiated Prices and a Defined Formulary. Feldman WB, Avorn J, Kesselheim AS. JAMA Intern Med . 2019 Dec 2. doi: 10.1001/jamainternmed.2019.5337.

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Oral Administration of miR-30d from Feces of MS Patients Suppresses MS-like Symptoms in Mice by Expanding Akkermansia muciniphila. Liu S, Rezende RM, Moreira TG, Tankou SK, Cox LM, [et al.] Weiner HL. Cell Host Microbe . 2019 Dec 11;26(6):779-794.e8. doi: 10.1016/j.chom.2019.10.008.

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PrEParing to End the HIV Epidemic - California's Route as a Road Map for the United States. Kazi DS, Katz IT, Jha AK. N Engl J Med . 2019 Dec 26;381(26):2489-2491. doi: 10.1056/NEJMp1912293.

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Age-Related Dopaminergic Innervation Augments T Helper 2-Type Allergic Inflammation in the Postnatal Lung. Wang W, Cohen JA, Wallrapp A, Trieu KG, Barrios J, [et al.] Ai X. Immunity . 2019 Dec 17;51(6):1102-1118.e7. doi: 10.1016/j.immuni.2019.10.002.

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The KDM5A/RBP2 histone demethylase represses NOTCH signaling to sustain neuroendocrine differentiation and promote small cell lung cancer tumorigenesis. Oser MG, Sabet AH, Gao W, Chakraborty AA, Schinzel AC, [et al.] Kaelin WG Jr. Genes Dev . 2019 Dec 1;33(23-24):1718-1738. doi: 10.1101/gad.328336.119.

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Metoprolol for the Prevention of Acute Exacerbations of COPD Dransfield MT, Voelker H, Bhatt SP, Brenner K, Casaburi R, [et al.] BLOCK COPD Trial Group. N Engl J Med . 2019 Dec 12;381(24):2304-2314. doi: 10.1056/NEJMoa1908142.

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