June 2021 The Science Spotlight newsletter features publications from Brigham researchers in high-impact journals. Recognizing that journal impact factor is not an absolute way to feature all scientific publications of significant merit, we welcome investigators to submit noteworthy articles to be featured in the newsletter through this REDCap survey. *The gold colored buttons denote COVID-19 related publications.

In May there were: 1,121 total papers listed in PubMed with Brigham authors 69 tweets about new research and 119K tweet impressions 3 press releases 8 research briefs 6 papers features in "What's New in Research" 67 awards with $34,607,077 in new grants

A Reminder from the Office of Strategic Communication: If you have research news to share, please contact us. Ideally, we work with researchers as soon as a paper is accepted at a journal to develop an appropriate communication strategy in advance of publication. For media relations and social media support, email mediarelations@bwh.harvard.edu or contact Haley Bridger directly at hbridger@bwh.harvard.edu Listen to the recording of the June RC LIVE Meeting, "What Makes the News for Researchers," with Haley Bridger. Listen to the recording here.

Comparative Effectiveness of Aspirin Dosing in Cardiovascular Disease. Jones WS, Mulder H, Wruck LM, Pencina MJ, Kripalani S, [et al.] Hernandez AF; ADAPTABLE Team. N Engl J Med. 2021 May 27;384(21):1981-1990. doi: 10.1056/NEJMoa2102137. Epub 2021 May 15. PMID: 33999548 Clinical Trial.

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Tezepelumab in Adults and Adolescents with Severe, Uncontrolled Asthma. Menzies-Gow A, Corren J, Bourdin A, Chupp G, Israel E, [et al.] Colice G. N Engl J Med. 2021 May 13;384(19):1800-1809. doi: 10.1056/NEJMoa2034975. PMID: 33979488 Clinical Trial.

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Gasdermin D pore structure reveals preferential release of mature interleukin-1. Xia S, Zhang Z, Magupalli VG, Pablo JL, Dong Y [et al.] Wu H. Nature. 2021 May;593(7860):607-611. doi: 10.1038/s41586-021-03478-3. Epub 2021 Apr 21. PMID: 33883744

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AI-based pathology predicts origins for cancers of unknown primary. Lu MY, Chen TY, Williamson DFK, Zhao M, Shady M, Lipkova J, Mahmood F. Nature. 2021 Jun;594(7861):106-110. doi: 10.1038/s41586-021-03512-4. Epub 2021 May 5. PMID: 33953404

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Mavacamten for treatment of symptomatic obstructive hypertrophic cardiomyopathy (EXPLORER-HCM): health status analysis of a randomised, double-blind, placebo-controlled, phase 3 trial. Spertus JA, Fine JT, Elliott P, Ho CY, Olivotto I, [et al.] Jacoby D. Lancet. 2021 Jun 26;397(10293):2467-2475. doi: 10.1016/S0140-6736(21)00763-7. Epub 2021 May 15. PMID: 34004177

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A framework for microbiome science in public health. Wilkinson JE, Franzosa EA, Everett C, Li C; HCMPH researchers and trainees, [et al.] Huttenhower C. Nat Med. 2021 May;27(5):766-774. doi: 10.1038/s41591-021-01258-0. Epub 2021 Apr 5. PMID: 33820996 Review.

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IL-6 inhibition with ziltivekimab in patients at high atherosclerotic risk (RESCUE): a double-blind, randomised, placebo-controlled, phase 2 trial. Ridker PM, Devalaraja M, Baeres FMM, Engelmann MDM, Hovingh GK, [et al.] Davidson M; RESCUE Investigators. Lancet. 2021 May 29;397(10289):2060-2069. doi: 10.1016/S0140-6736(21)00520-1. Epub 2021 May 17. PMID: 34015342

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Effect of Half-Dose vs Stable-Dose Conventional Synthetic Disease-Modifying Antirheumatic Drugs on Disease Flares in Patients With Rheumatoid Arthritis in Remission: The ARCTIC REWIND Randomized Clinical Trial. Lillegraven S, Paulshus Sundlisæter N, Aga AB, Sexton J, Olsen IC, [et al.] Haavardsholm EA. JAMA. 2021 May 4;325(17):1755-1764. doi: 10.1001/jama.2021.4542. PMID: 33944875 Clinical Trial.

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Epigenetic silencing by SETDB1 suppresses tumour intrinsic immunogenicity. Griffin GK, Wu J, Iracheta-Vellve A, Patti JC, Hsu J, [et al.] Bernstein BE. Nature. 2021 May 5. doi: 10.1038/s41586-021-03520-4. Online ahead of print. PMID: 33953401

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Women's Health - Traversing Medicine and Public Policy. Stuenkel CA, Manson JE. N Engl J Med. 2021 Jun 3;384(22):2073-2076. doi: 10.1056/NEJMp2105292. Epub 2021 May 29. PMID: 34080809 No abstract available.

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Rethinking vaccine hesitancy among minority groups. Khan MS, Ali SAM, Adelaine A, Karan A. Lancet. 2021 May 22;397(10288):1863-1865. doi: 10.1016/S0140-6736(21)00938-7. Epub 2021 Apr 21. PMID: 33894143 Free PMC article. No abstract available

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Therapeutically reprogrammed nutrient signalling enhances nanoparticulate albumin bound drug uptake and efficacy in KRAS-mutant cancer. Li R, Ng TSC, Wang SJ, Prytyskach M, Rodell CB, [et al.] Miller MA. Nat Nanotechnol. 2021 May 6. doi: 10.1038/s41565-021-00897-1. Online ahead of print. PMID: 33958764

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Phase II Study of the WEE1 Inhibitor Adavosertib in Recurrent Uterine Serous Carcinoma. Liu JF, Xiong N, Campos SM, Wright AA, Krasner C, [et al.] Konstantinopoulos PA. J Clin Oncol. 2021 May 10;39(14):1531-1539. doi: 10.1200/JCO.20.03167. Epub 2021 Mar 11. PMID: 33705205

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Dynamic landscape of immune cell-specific gene regulation in immune-mediated diseases. Ota M, Nagafuchi Y, Hatano H, Ishigaki K, Terao C, [et al.] Fujio K. Cell. 2021 May 27;184(11):3006-3021.e17. doi: 10.1016/j.cell.2021.03.056. Epub 2021 May 1. PMID: 33930287

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Equitable allocation of COVID-19 vaccines in the United States. Schmidt H, Weintraub R, Williams MA, Miller K, Buttenheim A, [et al.] Shen AA. Nat Med. 2021 May 18. doi: 10.1038/s41591-021-01379-6. Online ahead of print. PMID: 34007071

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Tocilizumab in COVID-19: some clarity amid controversy. Gupta S, Leaf DE. Lancet. 2021 May 1;397(10285):1599-1601. doi: 10.1016/S0140-6736(21)00712-1. PMID: 33933194 Free PMC article. No abstract available.

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Evaluation of Aducanumab for Alzheimer Disease: Scientific Evidence and Regulatory Review Involving Efficacy, Safety, and Futility. Alexander GC, Emerson S, Kesselheim AS. JAMA. 2021 May 4;325(17):1717-1718. doi: 10.1001/jama.2021.3854. PMID: 33783469 No abstract available.

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Inhaled Treprostinil in Group 3 Pulmonary Hypertension. Reply. Nathan SD, Waxman A, Tapson V. N Engl J Med. 2021 May 13;384(19):1871-1872. doi: 10.1056/NEJMc2103465. PMID: 33979501 No abstract available.

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Targeting inflammation in atherosclerosis - from experimental insights to the clinic. Soehnlein O, Libby P. Nat Rev Drug Discov. 2021 May 11:1-22. doi: 10.1038/s41573-021-00198-1. Online ahead of print. PMID: 33976384 Free PMC article. Review.

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Hidden Biomass of Intact Malaria Parasites in the Human Spleen. Kho S, Qotrunnada L, Leonardo L, Andries B, Wardani PAI, [et al.] Anstey NM. N Engl J Med. 2021 May 27;384(21):2067-2069. doi: 10.1056/NEJMc2023884. PMID: 34042394 No abstract available.

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Dietary risk versus physical inactivity: a forced comparison with policy implications? Ding D, Lee IM, Bauman AE, Ekelund U, Stamatakis E. Lancet. 2021 May 8;397(10286):1709-1710. doi: 10.1016/S0140-6736(21)00801-1. PMID: 33965086 No abstract available.

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Mortality From Drug Overdoses, Homicides, Unintentional Injuries, Motor Vehicle Crashes, and Suicides During the Pandemic, March-August 2020. Faust JS, Du C, Mayes KD, Li SX, Lin Z, Barnett ML, Krumholz HM. JAMA. 2021 May 21:e218012. doi: 10.1001/jama.2021.8012. Online ahead of print. PMID: 34019096

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Decision Making in Older Adults With Cancer. DuMontier C, Loh KP, Soto-Perez-de-Celis E, Dale W. J Clin Oncol. 2021 May 27:JCO2100165. doi: 10.1200/JCO.21.00165. Online ahead of print. PMID: 34043434 No abstract available.

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Mass-Vaccination Sites - An Essential Innovation to Curb the Covid-19 Pandemic. Goralnick E, Kaufmann C, Gawande AA. N Engl J Med. 2021 May 6;384(18):e67. doi: 10.1056/NEJMp2102535. Epub 2021 Mar 10. PMID: 33691058 No abstract available.

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SARS-CoV-2 evolution in an immunocompromised host reveals shared neutralization escape mechanisms. Clark SA, Clark LE, Pan J, Coscia A, McKay LGA, [et al.] Abraham J. Cell. 2021 May 13;184(10):2605-2617.e18. doi: 10.1016/j.cell.2021.03.027. Epub 2021 Mar 16. PMID: 33831372 Free PMC article.

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Extended-representation bisulfite sequencing of gene regulatory elements in multiplexed samples and single cells. Shareef SJ, Bevill SM, Raman AT, Aryee MJ, van Galen P, Hovestadt V, Bernstein BE. Nat Biotechnol. 2021 May 6. doi: 10.1038/s41587-021-00910-x. Online ahead of print. PMID: 33958785

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Other Featured Publications

Nurse-Doctor Co-Teaching: A Pilot Study of the Design, Development, and Implementation of Structured Interprofessional Co-Teaching Sessions Zambrotta ME, Aylward P, Roy CL, Piper-Vallillo E, Pelletier SR, [et al.] Shields HM Adv Med Educ Pract. 2021 Apr 16;12:339-348. doi: 10.2147/AMEP.S300231. PMID: 33889044; PMCID: PMC8057953.

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Training Residents in Virtual Advance Care Planning: A New Twist in Telehealth Mills S, Cioletti A, Gingell G, Ramani S. J Pain Symptom Manage. 2021 Apr 2:S0885-3924(21)00273-6. doi: 10.1016/j.jpainsymman.2021.03.019. Epub ahead of print. PMID: 33819515.

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The COVID-19 Online Learning Transition and the Plus/Delta Debriefing Model Dzara K, Heller A, Kesselheim J. J Contin Educ Health Prof. 2021 Apr 1;41(2):91-93. doi: 10.1097/CEH.0000000000000359. PMID: 33929354.

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Genome-wide survival study identifies a novel synaptic locus and polygenic score for cognitive progression in Parkinson's disease Liu G, Peng J, Liao Z, Locascio JJ, Corvol JC, [et al.] International Genetics of Parkinson Disease Progression (IGPP) Consortium, Scherzer CR. Nat Genet. 2021 Jun;53(6):787-793. doi: 10.1038/s41588-021-00847-6. Epub 2021 May 6. PMID: 33958783.

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Effects of a refined evidence-based toolkit and mentored implementation on medication reconciliation at 18 hospitals: results of the MARQUIS2 study Schnipper JL, Reyes Nieva H, Mallouk M, Mixon A, Rennke S, [et al.] Kripalani S; and MARQUIS2 Site Leaders; MARQUIS2 Study Group. BMJ Qual Saf. 2021 Apr 29:bmjqs-2020-012709. doi: 10.1136/bmjqs-2020-012709. Epub ahead of print. PMID: 33927025.

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Structures of chaperone-associated assembly intermediates reveal coordinated mechanisms of proteasome biogenesis. Schnell HM, Walsh RM Jr, Rawson S, Kaur M, Bhanu MK, [et al.] Hanna J. Nat Struct Mol Biol. 2021 May;28(5):418-425. doi: 10.1038/s41594-021-00583-9. Epub 2021 Apr 12. PMID: 33846632; PMCID: PMC8160580.

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Submit Your Publication to Science Spotlight We recognize there are many other Brigham publications in Journals that may not be included on this list, so we would like to extend the opportunity to our research community. If you and/or your Brigham colleagues are the first and/or last author on a recent publication, we want to include you in our Science Spotlight newsletter! Please fill out this brief REDCap form with the details of your publication.

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