November 2020 The Science Spotlight newsletter features publications from Brigham researchers in high-impact journals and research metrics from the prior month. The gold colored buttons denote COVID-19 related publications. Brigham authors are bolded.

In October there were: 49 papers led by Brigham researchers published in top-tier journals 45 tweets about new research and 42.2K tweet impressions 2 press releases 3 research briefs 54 awards with $17,699,548 in new grants

Cardiovascular Outcomes with Ertugliflozin in Type 2 Diabetes. Cannon CP, Pratley R, Dagogo-Jack S, Mancuso J, Huyck S, [et al.] McGuire DK; VERTIS CV Investigators. N Engl J Med. 2020 Oct 8;383(15):1425-1435. doi: 10.1056/NEJMoa2004967. Epub 2020 Sep 23.PMID: 32966714

Read the paper

Targeting the HIF2-VEGF axis in renal cell carcinoma. Choueiri TK, Kaelin WG Jr. Nat Med. 2020 Oct;26(10):1519-1530. doi: 10.1038/s41591-020-1093-z. Epub 2020 Oct 5.PMID: 33020645

Read the paper

A Phase Ib Trial of Personalized Neoantigen Therapy Plus Anti-PD-1 in Patients with Advanced Melanoma, Non-small Cell Lung Cancer, or Bladder Cancer. Ott PA, Hu-Lieskovan S, Chmielowski B, Govindan R, Naing A, [et al.] Srinivasan L. Cell. 2020 Oct 15;183(2):347-362.e24. doi: 10.1016/j.cell.2020.08.053.PMID: 33064988

Read the paper

Efficacy of Tocilizumab in Patients Hospitalized with Covid-19. Stone JH, Frigault MJ, Serling-Boyd NJ, Fernandes AD, Harvey L, [et al.] Mansour MK; BACC Bay Tocilizumab Trial Investigators. N Engl J Med. 2020 Oct 21. doi: 10.1056/NEJMoa2028836. Online ahead of print.PMID: 33085857

Read the paper

Transcriptional Reprogramming of Distinct Peripheral Sensory Neuron Subtypes after Axonal Injury. Renthal W, Tochitsky I, Yang L, Cheng YC, Li E, Kawaguchi R, Geschwind DH, Woolf CJ. Neuron. 2020 Oct 14;108(1):128-144.e9. doi: 10.1016/j.neuron.2020.07.026. Epub 2020 Aug 17.PMID: 32810432

Read the paper

Burden of non-communicable diseases from infectious causes in 2017: a modelling study. Coates MM, Kintu A, Gupta N, Wroe EB, Adler AJ, [et al.] Bukhman G. Lancet Glob Health. 2020 Oct 21:S2214-109X(20)30358-2. doi: 10.1016/S2214-109X(20)30358-2. Online ahead of print.PMID: 33098769

Read the paper

Association Between Early Treatment With Tocilizumab and Mortality Among Critically Ill Patients With COVID-19. Gupta S, Wang W, Hayek SS, Chan L, Mathews KS, [et al.] Leaf DE; STOP-COVID Investigators. JAMA Intern Med. 2020 Oct 20:e206252. doi: 10.1001/jamainternmed.2020.6252. Online ahead of print.PMID: 33080002

Read the paper

Delayed Denosumab Injections and Fracture Risk Among Patients With Osteoporosis : A Population-Based Cohort Study. Lyu H, Yoshida K, Zhao SS, Wei J, Zeng C, [et al.] Solomon DH. Ann Intern Med. 2020 Oct 6;173(7):516-526. doi: 10.7326/M20-0882. Epub 2020 Jul 28.PMID: 32716706

Read the paper

Secondary Mitral Regurgitation. O'Gara PT, Mack MJ. N Engl J Med. 2020 Oct 8;383(15):1458-1467. doi: 10.1056/NEJMcp1903331.PMID: 33027570

Read the paper

Neoadjuvant atezolizumab in combination with sequential nab-paclitaxel and anthracycline-based chemotherapy versus placebo and chemotherapy in patients with early-stage triple-negative breast cancer (IMpassion031): a randomised, double-blind, phase 3 trial. Mittendorf EA, Zhang H, Barrios CH, Saji S, Jung KH, [et al.] Harbeck N. Lancet. 2020 Oct 10;396(10257):1090-1100. doi: 10.1016/S0140-6736(20)31953-X. Epub 2020 Sep 20.PMID: 32966830

Read the paper

The structure of a calsequestrin filament reveals mechanisms of familial arrhythmia. Titus EW, Deiter FH, Shi C, Wojciak J, Scheinman M, Jura N, Deo RC. Nat Struct Mol Biol. 2020 Oct 12. doi: 10.1038/s41594-020-0510-9. Online ahead of print.PMID: 33046906

Read the paper

SARS-CoV-2 viral load is associated with increased disease severity and mortality. Fajnzylber J, Regan J, Coxen K, Corry H, Wong C, [et al.] Li JZ; Massachusetts Consortium for Pathogen Readiness. Nat Commun. 2020 Oct 30;11(1):5493. doi: 10.1038/s41467-020-19057-5.PMID: 33127906

Read the paper

Effects of Interleukin-1β Inhibition on Incident Hip and Knee Replacement : Exploratory Analyses From a Randomized, Double-Blind, Placebo-Controlled Trial. Schieker M, Conaghan PG, Mindeholm L, Praestgaard J, Solomon DH, [et al.] Ridker PM. Ann Intern Med. 2020 Oct 6;173(7):509-515. doi: 10.7326/M20-0527. Epub 2020 Aug 4.PMID: 32744862

Read the paper

Coordination of Grp1 recruitment mechanisms by its phosphorylation. Li J, Lambright DG, Hsu VW. Mol Biol Cell. 2020 Oct 7:mbcE20030173. doi: 10.1091/mbc.E20-03-0173. Online ahead of print.PMID: 33026967

Read the paper

Sensory Ganglionopathy. Amato AA, Ropper AH. N Engl J Med. 2020 Oct 22;383(17):1657-1662. doi: 10.1056/NEJMra2023935.PMID: 33085862

Read the paper

Increased power from conditional bacterial genome-wide association identifies macrolide resistance mutations in Neisseria gonorrhoeae. Ma KC, Mortimer TD, Duckett MA, Hicks AL, Wheeler NE, Sánchez-Busó L, Grad YH. Nat Commun. 2020 Oct 23;11(1):5374. doi: 10.1038/s41467-020-19250-6.PMID: 33097713

Read the paper

Despair and the shame of personal responsibility. Nabi J. Lancet. 2020 Oct 3;396(10256):956. doi: 10.1016/S0140-6736(20)32017-1.PMID: 33010837

Read the paper

Medicine and Grief During the COVID-19 Era: The Art of Losing. Maitra A. JAMA Intern Med. 2020 Oct 26. doi: 10.1001/jamainternmed.2020.5635. Online ahead of print.PMID: 33104160

Read the paper

Reentry. Leiter RE. N Engl J Med. 2020 Oct 14. doi: 10.1056/NEJMp2027447. Online ahead of print.PMID: 33053276

Read the paper

The Lancet NCDI Poverty Commission: bridging a gap in universal health coverage for the poorest billion. Bukhman G, Mocumbi AO, Atun R, Becker AE, Bhutta Z, [et al.] Mayosi B; Lancet NCDI Poverty Commission Study Group. Lancet. 2020 Oct 3;396(10256):991-1044. doi: 10.1016/S0140-6736(20)31907-3. Epub 2020 Sep 14.PMID: 32941823

Read the paper

Inflammatory Biomarker Trends Predict Respiratory Decline in COVID-19 Patients. Mueller AA, Tamura T, Crowley CP, DeGrado JR, Haider H, [et al.] Kim EY. Cell Rep Med. 2020 Oct 29:100144. doi: 10.1016/j.xcrm.2020.100144. Online ahead of print.PMID: 33163981

Read the paper

Building Longitudinal Relationships Into a Traditional Block Clerkship Model: A Mixed-Methods Study. Atalay AJ, Osman NY, Krupat E, Alexander EK. Acad Med. 2020 Oct 27. doi: 10.1097/ACM.0000000000003810. Online ahead of print.PMID: 33116060

Read the paper

Safety and immunogenicity of two heterologous HIV vaccine regimens in healthy, HIV-uninfected adults (TRAVERSE): a randomised, parallel-group, placebo-controlled, double-blind, phase 1/2a study. Baden LR, Stieh DJ, Sarnecki M, Walsh SR, Tomaras GD, [et al.] Tomaka F; Traverse/HVTN 117/HPX2004 Study Team. Lancet HIV. 2020 Oct;7(10):e688-e698. doi: 10.1016/S2352-3018(20)30229-0.PMID: 33010242

Read the paper

Surprise Billing for Colonoscopy: The Scope of the Problem. Scheiman JM, Fendrick AM, Nuliyalu U, Ryan AM, Chhabra KR. Ann Intern Med. 2020 Oct 13. doi: 10.7326/M20-2928. Online ahead of print.PMID: 33045178

Read the paper

Resident Leadership in the Era of COVID-19: Harnessing Emotional Intelligence. Ward HB. Acad Med. 2020 Oct;95(10):1521-1523. doi: 10.1097/ACM.0000000000003558.PMID: 33006869

Read the paper

Insurance Coverage after Job Loss - The Importance of the ACA during the Covid-Associated Recession. Agarwal SD, Sommers BD. N Engl J Med. 2020 Oct 22;383(17):1603-1606. doi: 10.1056/NEJMp2023312. Epub 2020 Aug 19.PMID: 32813967

Read the paper

Physician Work Hours and the Gender Pay Gap - Evidence from Primary Care. Ganguli I, Sheridan B, Gray J, Chernew M, Rosenthal MB, Neprash H. N Engl J Med. 2020 Oct 1;383(14):1349-1357. doi: 10.1056/NEJMsa2013804.PMID: 32997909

Read the paper

Seasonal Influenza Vaccination. Solomon DA. JAMA. 2020 Oct 6;324(13):1362. doi: 10.1001/jama.2020.14772.PMID: 32797144

Read the paper

Ensuring Safe Access to Mifepristone During the Pandemic and Beyond. Brown BL, Wood SF, Sarpatwari A. Ann Intern Med. 2020 Oct 21:M20-6671. doi: 10.7326/M20-6671. Online ahead of print.PMID: 33085508

Read the paper

Parroting Lymphoma. Anderson JD, Ho VT, Wright KT, Levy BD, Loscalzo J. N Engl J Med. 2020 Oct 1;383(14):1376-1381. doi: 10.1056/NEJMcps1915728.PMID: 32997914

Read the paper

Author Correction: AHR is a Zika virus host factor and a candidate target for antiviral therapy. Giovannoni F, Bosch I, Polonio CM, Torti MF, Wheeler MA, [et al.] Quintana FJ. Nat Neurosci. 2020 Oct;23(10):1307. doi: 10.1038/s41593-020-0700-0.PMID: 32778795

Read the paper

The Unrecognized Prevalence of Primary Aldosteronism. Vaidya A, Brown JM, Carey RM, Siddiqui M, Williams GH. Ann Intern Med. 2020 Oct 20;173(8):683. doi: 10.7326/L20-1097.PMID: 33075250 No abstract available.

Read the paper

Holding Up. Maitra A. N Engl J Med. 2020 Oct 14. doi: 10.1056/NEJMp2025395. Online ahead of print.PMID: 33053278

Read the paper

Pulmonary vascular dysfunction among people aged over 65 years in the community in the Atherosclerosis Risk In Communities (ARIC) Study: A cross-sectional analysis. Teramoto K, Santos M, Claggett B, John JE, Solomon SD, [et al.] Shah AM. PLoS Med. 2020 Oct 15;17(10):e1003361. doi: 10.1371/journal.pmed.1003361. eCollection 2020 Oct.PMID: 33057391

Read the paper

Maternal healthcare coverage for first pregnancies in adolescent girls: a systematic comparison with adult mothers in household surveys across 105 countries, 2000-2019. Li Z, Patton G, Sabet F, Subramanian SV, Lu C. BMJ Glob Health. 2020 Oct;5(10):e002373. doi: 10.1136/bmjgh-2020-002373.PMID:

Read the paper

Web Exclusive. Annals On Call - Underdiagnosis of Primary Aldosteronism. Centor RM, Brown JM. Ann Intern Med. 2020 Oct 20;173(8):OC1. doi: 10.7326/A19-0040.PMID: 33075251

Read the paper

Up Is Down - Pharmaceutical Industry Caution vs. Federal Acceleration of Covid-19 Vaccine Approval. Avorn J, Kesselheim AS. N Engl J Med. 2020 Oct 29;383(18):1706-1708. doi: 10.1056/NEJMp2029479. Epub 2020 Sep 15.PMID: 32931162

Read the paper

Influenza in the COVID-19 Era. Solomon DA, Sherman AC, Kanjilal S. JAMA. 2020 Oct 6;324(13):1342-1343. doi: 10.1001/jama.2020.14661.PMID: 32797145

Read the paper

Timing of radiotherapy after radical prostatectomy Tilki D, D'Amico AV. Lancet. 2020 Oct 31;396(10260):1374-1375. doi: 10.1016/S0140-6736(20)31957-7. Epub 2020 Sep 28.PMID: 33002430

Read the paper

Dystopian Diary of a Medical Resident. Vise AS. JAMA Intern Med. 2020 Oct 1;180(10):1277. doi: 10.1001/jamainternmed.2020.2780.PMID: 32702092

Read the paper

Transparency and reproducibility in artificial intelligence. Haibe-Kains B, Adam GA, Hosny A, Khodakarami F; Massive Analysis Quality Control (MAQC) Society Board of Directors, [et al.] Aerts HJWL. Nature. 2020 Oct;586(7829):E14-E16. doi: 10.1038/s41586-020-2766-y. Epub 2020 Oct 14.PMID: 33057217

Read the paper

White Coats for Black Lives: The Time Has Come for Action. Stone VE. Ann Intern Med. 2020 Oct 20;173(8):656-657. doi: 10.7326/M20-4280. Epub 2020 Jun 18.PMID: 32551811

Read the paper

The microbiome requires a genetically susceptible host to induce central nervous system autoimmunity. Cox LM, Weiner HL. Proc Natl Acad Sci U S A. 2020 Nov 10;117(45):27764-27766. doi: 10.1073/pnas.2020106117. Epub 2020 Oct 29.PMID: 33122445

Read the paper

In adults with severe acute GI bleeding, tranexamic acid did not reduce death due to bleeding at 5 days. Horton LC, Feuerstein JD. Ann Intern Med. 2020 Oct 20;173(8):JC46. doi: 10.7326/ACPJ202010200-046.PMID: 33075257

Read the paper

A One-Two Punch in the Gut May Trigger Multiple Sclerosis. Maghzi AH, Weiner HL. Immunity. 2020 Oct 13;53(4):707-709. doi: 10.1016/j.immuni.2020.09.016.PMID: 33053328

Read the paper

Regulatory Decision-making on COVID-19 Vaccines During a Public Health Emergency. Avorn J, Kesselheim A. JAMA. 2020 Oct 6;324(13):1284-1285. doi: 10.1001/jama.2020.17101.PMID: 32870268

Read the paper

COVID-19 Test Result Turnaround Time for Residents and Staff in US Nursing Homes. McGarry BE, SteelFisher GK, Grabowski DC, Barnett ML. JAMA Intern Med. 2020 Oct 30:e207330. doi: 10.1001/jamainternmed.2020.7330. Online ahead of print.PMID: 33125044

Read the paper

Vericiguat in Heart Failure with Reduced Ejection Fraction. Ryan JJ, Maron BA. N Engl J Med. 2020 Oct 8;383(15):1497. doi: 10.1056/NEJMc2027731.PMID: 33027578 No

Read the paper

A Multifactorial Trial to Prevent Serious Fall Injuries. Reply. Bhasin S, Gill TM, Reuben DB. N Engl J Med. 2020 Oct 1;383(14):1395-1396. doi: 10.1056/NEJMc2026944.PMID: 32997924

Read the paper

Spotlight on Education Related Publications

Twelve tips for developing a global community of scholars in health professions education Ramani S, McKimm J, Findyartini A, Nadarajah VD, Hays R, [et al.] Wilson KW. Med Teach. 2020 Oct 27:1-6. doi: 10.1080/0142159X.2020.1839034. Epub ahead of print. PMID: 33108740.

Read the paper

**Please visit the new MGB web page for COVID funding opportunities that provides a central database for researchers to view open and competitive funding announcements***

Questions, comments, or concerns? Please reach out to our Research Helpline ResearchHelpline@bwh.harvard.edu with any and all of your research related inquiries!