March 2021
The Science Spotlight newsletter previously featured publications from Brigham researchers in high-impact journals collated by Harvard Paper Chase. This list has since been discontinued. Going forward papers from journals with the highest impact factors will be highlighted. Recognizing that journal impact factor is not an absolute way to feature all scientific publications of significant merit, we welcome investigators to submit noteworthy articles to be featured in the newsletter through this REDCap survey.

*The gold colored buttons denote COVID-19 related publications.
In March there were:
1,183 total papers listed in PubMed with Brigham authors
58 tweets about new research and 144K tweet impressions
50 awards with $28,619,034 in new grants
A Reminder from the Office of Strategic Communication: If you have research news to share, please contact us. Ideally, we work with researchers as soon as a paper is accepted at a journal to develop an appropriate communication strategy in advance of publication. For media relations and social media support, email mediarelations@bwh.harvard.edu or contact Haley Bridger directly at hbridger@bwh.harvard.edu
Hu Z, Leet DE, Allesøe RL, Oliveira G, Li S [et. al] Ott PA.
Nat Med. 2021 Mar;27(3):515-525. doi: 10.1038/s41591-020-01206-4. Epub 2021 Jan 21.
PMID: 33479501
Stout NL, Santa Mina D, Lyons KD, Robb K, Silver JK.
CA Cancer J Clin. 2021 Mar;71(2):149-175. doi: 10.3322/caac.21639. Epub 2020 Oct 27.
PMID: 33107982
Choueiri TK, Powles T, Burotto M, Escudier B, Bourlon MT [et al.] Motzer RJ; CheckMate 9ER Investigators.
N Engl J Med. 2021 Mar 4;384(9):829-841. doi: 10.1056/NEJMoa2026982.
PMID: 33657295 
Biswas S, Mandal G, Payne KK, Anadon CM, Gatenbee CD, [et. al] Conejo-Garcia JR.
Nature. 2021 Mar;591(7850):464-470. doi: 10.1038/s41586-020-03144-0. Epub 2021 Feb 3.
PMID: 33536615
Corey L, Gilbert PB, Juraska M, Montefiori DC, Morris L [et. al] Cohen MS; HVTN 704/HPTN 085 and HVTN 703/HPTN 081 Study Teams.
N Engl J Med. 2021 Mar 18;384(11):1003-1014. doi: 10.1056/NEJMoa2031738.
PMID: 33730454
Nalbandian A, Sehgal K, Gupta A, Madhavan MV, McGroder C, [et. al] Wan EY.
Nat Med. 2021 Apr;27(4):601-615. doi: 10.1038/s41591-021-01283-z. Epub 2021 Mar 22.
PMID: 33753937 
Kirtane AR, Verma M, Karandikar P, Furin J, Langer R, Traverso G.
Nat Nanotechnol. 2021 Apr;16(4):369-384. doi: 10.1038/s41565-021-00866-8. Epub 2021 Mar 22.
PMID: 33753915 
Dougan M, Luoma AM, Dougan SK, Wucherpfennig KW.
Cell. 2021 Mar 18;184(6):1575-1588. doi: 10.1016/j.cell.2021.02.011. Epub 2021 Mar 5.
PMID: 33675691 
Leiter RE.
N Engl J Med. 2021 Mar 18;384(11):986-987. doi: 10.1056/NEJMp2004154. Epub 2021 Mar 13.
PMID: 33734648
Muus C, Luecken MD, Eraslan G, Sikkema L, Waghray A, [et. al] Ziegler CGK; NHLBI LungMap Consortium; Human Cell Atlas Lung Biological Network.
Nat Med. 2021 Mar;27(3):546-559. doi: 10.1038/s41591-020-01227-z. Epub 2021 Mar 2.
PMID: 33654293
Albert CM, Cook NR, Pester J, Moorthy MV, Ridge C, [et. al] Manson JE.
JAMA. 2021 Mar 16;325(11):1061-1073. doi: 10.1001/jama.2021.1489.
PMID: 33724323 
Erlinge D, Maehara A, Ben-Yehuda O, Bøtker HE, Maeng M, [et. al.] Stone GW; PROSPECT II Investigators.
Lancet. 2021 Mar 13;397(10278):985-995. doi: 10.1016/S0140-6736(21)00249-X.
PMID: 33714389
Xu W, Li J, He C, Wen J, Ma H, [et. al.] Shen H.
Nature. 2021 Mar;591(7849):317-321. doi: 10.1038/s41586-021-03210-1. Epub 2021 Jan 27.
PMID: 33505026
Wang YX, Mínguez-Alarcón L, Gaskins AJ, Missmer SA, Rich-Edwards JW, [et. al.] Chavarro JE.
BMJ. 2021 Mar 24;372:n530. doi: 10.1136/bmj.n530.
PMID: 33762255 
Page MJ, Moher D, Bossuyt PM, Boutron I, Hoffmann TC, [et. al.] McKenzie JE.
BMJ. 2021 Mar 29;372:n160. doi: 10.1136/bmj.n160.
PMID: 33781993 
Fidler TP, Xue C, Yalcinkaya M, Hardaway B, Abramowicz S, [et. al.] Tall AR.
Nature. 2021 Apr;592(7853):296-301. doi: 10.1038/s41586-021-03341-5. Epub 2021 Mar 17.
PMID: 33731931
He MX, Cuoco MS, Crowdis J, Bosma-Moody A, Zhang Z, [et. al.] Van Allen EM.
Nat Med. 2021 Mar;27(3):426-433. doi: 10.1038/s41591-021-01244-6. Epub 2021 Mar 4.
PMID: 33664492 
Strauss DH, White SA, Bierer BE.
Science. 2021 Mar 19;371(6535):1209-1211. doi: 10.1126/science.abf2170.
PMID: 33737478
Page MJ, McKenzie JE, Bossuyt PM, Boutron I, Hoffmann TC, [et. al.] Moher D.
BMJ. 2021 Mar 29;372:n71. doi: 10.1136/bmj.n71.
PMID: 33782057 
Jilg N, Lau ES, Baker MA, Levy BD, Loscalzo J.
N Engl J Med. 2021 Mar 4;384(9):860-865. doi: 10.1056/NEJMcps2020668.
PMID: 33657298 
Mathewson ND, Ashenberg O, Tirosh I, Gritsch S, Perez EM, [et. al.] Wucherpfennig KW.
Cell. 2021 Mar 4;184(5):1281-1298.e26. doi: 10.1016/j.cell.2021.01.022. Epub 2021 Feb 15.
PMID: 33592174
Reker D, Rybakova Y, Kirtane AR, Cao R, Yang JW, [et. al.] Traverso G.
Nat Nanotechnol. 2021 Mar 25. doi: 10.1038/s41565-021-00870-y. Online ahead of print.
PMID: 33767382
Liu JF, Xiong N, Campos SM, Wright AA, Krasner C, [et. al.] Konstantinopoulos PA.
J Clin Oncol. 2021 Mar 11:JCO2003167. doi: 10.1200/JCO.20.03167. Online ahead of print.
PMID: 33705205
Bizzotto S, Dou Y, Ganz J, Doan RN, Kwon M, [et. al.] Walsh CA.
Science. 2021 Mar 19;371(6535):1249-1253. doi: 10.1126/science.abe1544.
PMID: 33737485
Chhabra KR, Fuse Brown E, Ryan AM.
N Engl J Med. 2021 Apr 15;384(15):1381-1383. doi: 10.1056/NEJMp2035905. Epub 2021 Mar 17.
PMID: 33730453 
Barsky BA, Reinhart E, Farmer P, Keshavjee S.
N Engl J Med. 2021 Mar 3. doi: 10.1056/NEJMp2100609. Online ahead of print.
PMID: 33657290
Castells MC, Phillips EJ.
N Engl J Med. 2021 Mar 11;384(10):e37. doi: 10.1056/NEJMc2100766. Epub 2021 Feb 10.
PMID: 33567190
Gibbons GH, Seidman CE, Topol EJ.
N Engl J Med. 2021 Mar 4;384(9):785-788. doi: 10.1056/NEJMp2033115. Epub 2021 Feb 27.
PMID: 33657686
Rotenstein LS, Reede JY, Jena AB.
N Engl J Med. 2021 Mar 25;384(12):1083-1086. doi: 10.1056/NEJMp2032224. Epub 2021 Mar 20.
PMID: 33764706
Pennell PB, Meador KJ.
N Engl J Med. 2021 Mar 11;384(10):977-978. doi: 10.1056/NEJMc2101226.
PMID: 33704955
Leaf DE, Ginde AA.
JAMA. 2021 Mar 16;325(11):1047-1048. doi: 10.1001/jama.2020.26850.
PMID: 33595641
Blumenthal KG, Freeman EE, Saff RR, Robinson LB, Wolfson AR, [et. al.] Shenoy ES.
N Engl J Med. 2021 Apr 1;384(13):1273-1277. doi: 10.1056/NEJMc2102131. Epub 2021 Mar 3.
PMID: 33657292 
Kesselheim AS, Hwang TJ, Avorn J.
JAMA. 2021 Mar 2;325(9):819-820. doi: 10.1001/jama.2021.0009.
PMID: 33651097
Garcia-Beltran WF, Lam EC, St Denis K, Nitido AD, Garcia ZH, [et. al.] Balazs AB.
Cell. 2021 Mar 12:S0092-8674(21)00298-1. doi: 10.1016/j.cell.2021.03.013. Online ahead of print.
PMID: 33743213 
Alexander GC, Emerson S, Kesselheim AS.
JAMA. 2021 Mar 30. doi: 10.1001/jama.2021.3854. Online ahead of print.
PMID: 33783469 
Goralnick E, Kaufmann C, Gawande AA.
N Engl J Med. 2021 Mar 10. doi: 10.1056/NEJMp2102535. Online ahead of print.
PMID: 33691058 
Sequist TD.
JAMA. 2021 Mar 16;325(11):1035-1036. doi: 10.1001/jama.2021.0521.
PMID: 33724330 
Kauke M, Panayi AC, Tchiloemba B, Diehm YF, Haug V, [et. al.] Pomahac B.
N Engl J Med. 2021 Mar 18;384(11):1075-1076. doi: 10.1056/NEJMc2033961.
PMID: 33730460 
Kolte D, Libby P, Jang IK.
JAMA. 2021 Mar 16;325(11):1043-1044. doi: 10.1001/jama.2021.0069.
PMID: 33616637 
Bick AG, Weinstock JS, Nandakumar SK, Fulco CP, Bao EL, [et. al.] Natarajan P.
Nature. 2021 Mar;591(7851):E27. doi: 10.1038/s41586-021-03280-1.
PMID: 33707633 
Bartsch YC, Wang C, Zohar T, Fischinger S, Atyeo C, [et. al.] Alter G.
Nat Med. 2021 Mar;27(3):454-462. doi: 10.1038/s41591-021-01263-3. Epub 2021 Feb 12.
PMID: 33589825
Clark SA, Clark LE, Pan J, Coscia A, McKay LGA, [et. al.] Abraham J.
Cell. 2021 Mar 16:S0092-8674(21)00355-X. doi: 10.1016/j.cell.2021.03.027. Online ahead of print.
PMID: 33831372 
Craig M, Jenner AL, Namgung B, Lee LP, Goldman A.
Chem Rev. 2021 Mar 24;121(6):3352-3389. doi: 10.1021/acs.chemrev.0c00356. Epub 2020 Nov 5.
PMID: 33152247
Muñoz-Rojas AR, Mathis D.
Nat Rev Immunol. 2021 Mar 26. doi: 10.1038/s41577-021-00519-w. Online ahead of print.
PMID: 33772242
Liu C, Shin J, Son S, Choe Y, Farokhzad N, [et. al] Tao W.
Chem Soc Rev. 2021 Mar 1;50(4):2260-2279. doi: 10.1039/d0cs01175d.
PMID: 33367452
Gyawali B, Kesselheim AS.
Nat Rev Clin Oncol. 2021 Mar 25. doi: 10.1038/s41571-021-00504-1. Online ahead of print.
PMID: 33767454
Other Featured Publications
Kovalenko A, Sanin A, Kosmas K, Zhang L, Wang J [et. al] Filippakis H.
Cancer Res. 2021 Feb 16:canres.2218.2020. doi: 10.1158/0008-5472.CAN-20-2218. Epub ahead of print. PMID: 33593821.
Van Egeren D, Escabi J, Nguyen M, Liu S, Reilly CR, [et. al] Hormoz S.
Cell Stem Cell. 2021 Mar 4;28(3):514-523.e9. doi: 10.1016/j.stem.2021.02.001. Epub 2021 Feb 22. PMID: 33621486; PMCID: PMC7939520.
Zhang M, Gui M, Wang ZF, Gorgulla C, Yu JJ, [et. al] Wagner G.
Nat Struct Mol Biol. 2021 Mar;28(3):258-267. doi: 10.1038/s41594-020-00554-6. Epub 2021 Feb 25. PMID: 33633398.
Chaudhari SN, Harris DA, Aliakbarian H, Luo JN, Henke MT, [et al.] Devlin AS.
Nat Chem Biol. 2021 Jan;17(1):20-29. doi: 10.1038/s41589-020-0604-z. Epub 2020 Aug 3. PMID: 32747812; PMCID: PMC7891870.
Worley JN, Javkar K, Hoffmann M, Hysell K, Garcia-Williams A, [et. al] Bry L.
mBio. 2021 Jan 26;12(1):e03188-20. doi: 10.1128/mBio.03188-20. PMID: 33500335; PMCID: PMC7858064.
Chaudhari SN, Luo JN, Harris DA, Aliakbarian H, Yao L, [et. al] Devlin AS.
Cell Host Microbe. 2021 Mar 10;29(3):408-424.e7. doi: 10.1016/j.chom.2020.12.004. Epub 2021 Jan 11. PMID: 33434516; PMCID: PMC7954942.
Fillmore N, DuMontier C, Yildirim C, La J, Epstein MM, [et. al] Driver JA.
J Natl Cancer Inst. 2021 Feb 1:djab007. doi: 10.1093/jnci/djab007. Epub ahead of print. PMID: 33523236.
Rahman SA, Sullivan JP, Barger LK, St Hilaire MA, O'Brien CS, [et. al] Lockley SW; ROSTERS STUDY GROUP.
Pediatrics. 2021 Mar;147(3):e2020009936. doi: 10.1542/peds.2020-009936. Epub 2021 Feb 22. PMID: 33619044; PMCID: PMC7919117.
Human airway mast cells proliferate and acquire distinct inflammation-driven phenotypes during type 2 inflammation
Dwyer DF, Ordovas-Montanes J, Allon SJ, Buchheit KM, Vukovic M, [et. al] Boyce JA.
Sci Immunol. 2021 Feb 26;6(56):eabb7221. doi: 10.1126/sciimmunol.abb7221. PMID: 33637594.
Iannuzzi D, Hall M, Oreskovic NM, Aryee E, Broder-Fingert S, Perrin JM, Kuhlthau KA.
J Autism Dev Disord. 2021 Mar 22. doi: 10.1007/s10803-021-04969-y. Epub ahead of print. PMID: 33751374.
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