June 2020 The Science Spotlight newsletter features publications from Brigham researchers in high-impact journals and funding updates from the prior month.

In May there were: 43 papers led by Brigham researchers published in top-tier journals 34 tweets about new research 40 awards with $39,694,832 in new grants

Coronavirus Disease 2019 (COVID-19): Protecting Hospitals From the Invisible. Klompas M. Ann Intern Med . 2020 May 5;172(9):619-620. doi: 10.7326/M20-0751. Epub 2020 Mar 11.PMID: 32160299

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MYC Controls the Epstein-Barr Virus Lytic Switch. Guo R, Jiang C, Zhang Y, Govande A, Trudeau SJ, [et al.] Gewurz BE. Mol Cell . 2020 May 21;78(4):653-669.e8. doi: 10.1016/j.molcel.2020.03.025. Epub 2020 Apr 20.PMID: 32315601

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Web Exclusive. Annals On Call - COVID-19: Is Chloroquine the Answer? Centor RM, Kim AH, Sparks JA. Ann Intern Med . 2020 May 5;172(9):OC1. doi: 10.7326/A20-0003. Epub 2020 Apr 9.PMID: 32271869 No abstract available.

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Pulmonary Vascular Endothelialitis, Thrombosis, and Angiogenesis in Covid-19. Ackermann M, Verleden SE, Kuehnel M, Haverich A, Welte T, [et al.] Jonigk D. N Engl J Med . 2020 May 21. doi: 10.1056/NEJMoa2015432. Online ahead of print.PMID: 32437596

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Sex and Gender Differences in Health: What the COVID-19 Pandemic Can Teach Us. Spagnolo PA, Manson JE, Joffe H. Ann Intern Med . 2020 May 8:M20-1941. doi: 10.7326/M20-1941. Online ahead of print.PMID: 32384135

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Remdesivir for 5 or 10 Days in Patients with Severe Covid-19. Goldman JD, Lye DCB, Hui DS, Marks KM, Bruno R, [et al.] Subramanian A; GS-US-540-5773 Investigators. N Engl J Med . 2020 May 27. doi: 10.1056/NEJMoa2015301. Online ahead of print.PMID: 32459919

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Merkel cell polyomavirus activates LSD1-mediated blockade of non-canonical BAF to regulate transformation and tumorigenesis. Park DE, Cheng J, McGrath JP, Lim MY, Cushman C, [et al.] DeCaprio JA. Nat Cell Biol . 2020 May;22(5):603-615. doi: 10.1038/s41556-020-0503-2. Epub 2020 Apr 13.PMID: 32284543

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The Unrecognized Prevalence of Primary Aldosteronism. Brown JM, Siddiqui M, Calhoun DA, Carey RM, Hopkins PN, Williams GH, Vaidya A. Ann Intern Med . 2020 May 26. doi: 10.7326/M20-0065. Online ahead of print.PMID: 32449886

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Loss of heterozygosity of essential genes represents a widespread class of potential cancer vulnerabilities. Nichols CA, Gibson WJ, Brown MS, Kosmicki JA, Busanovich JP, [et al.] Beroukhim R. Nat Commun . 2020 May 20;11(1):2517. doi: 10.1038/s41467-020-16399-y.PMID: 32433464

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Universal Masking in Hospitals in the Covid-19 Era. Klompas M, Morris CA, Sinclair J, Pearson M, Shenoy ES. N Engl J Med . 2020 May 21;382(21):e63. doi: 10.1056/NEJMp2006372. Epub 2020 Apr 1.PMID: 32237672 No abstract available.

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Most Patients Undergoing Ground And Air Ambulance Transportation Receive Sizable Out-Of-Network Bills. Chhabra KR, McGuire K, Sheetz KH, Scott JW, Nuliyalu U, Ryan AM. Health Aff  (Millwood). 2020 May;39(5):777-782. doi: 10.1377/hlthaff.2019.01484. Epub 2020 Apr 15.PMID: 32293925

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Prices and clinical benefit of cancer drugs in the USA and Europe: a cost-benefit analysis. Vokinger KN, Hwang TJ, Grischott T, Reichert S, Tibau A, Rosemann T, Kesselheim AS. Lancet Oncol . 2020 May;21(5):664-670. doi: 10.1016/S1470-2045(20)30139-X.PMID: 32359489

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A positively selected FBN1 missense variant reduces height in Peruvian individuals. Asgari S, Luo Y, Akbari A, Belbin GM, Li X, [et al.] Raychaudhuri S. Nature . 2020 Jun;582(7811):234-239. doi: 10.1038/s41586-020-2302-0. Epub 2020 May 13.PMID: 32499652

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Medicare's Care Management Codes Might Not Support Primary Care As Expected. Agarwal SD, Barnett ML, Souza J, Landon BE. Health Aff  (Millwood). 2020 May;39(5):828-836. doi: 10.1377/hlthaff.2019.00329.PMID: 32364873

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Prevalence and number of children living in institutional care: global, regional, and country estimates. Desmond C, Watt K, Saha A, Huang J, Lu C. Lancet Child Adolesc Health . 2020 May;4(5):370-377. doi: 10.1016/S2352-4642(20)30022-5. Epub 2020 Mar 6.PMID: 32151317

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Risk-benefit analysis of tuberculosis infection testing for household contact management in high-burden countries: a mathematical modelling study. Yuen CM, Seddon JA, Keshavjee S, Dodd PJ. Lancet Glob Health . 2020 May;8(5):e672-e680. doi: 10.1016/S2214-109X(20)30075-9.PMID: 32353315

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Tumor Interferon Signaling Is Regulated by a lncRNA INCR1 Transcribed from the PD-L1 Locus. Mineo M, Lyons SM, Zdioruk M, von Spreckelsen N, Ferrer-Luna R, [et al.] Chiocca EA. Mol Cell . 2020 May 28:S1097-2765(20)30316-6. doi: 10.1016/j.molcel.2020.05.015. Online ahead of print.PMID: 32504554

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Assessment of Deaths From COVID-19 and From Seasonal Influenza. Faust JS, Del Rio C. JAMA  Intern Med. 2020 May 14. doi: 10.1001/jamainternmed.2020.2306. Online ahead of print.PMID: 32407441 No abstract available.

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Challenges in the interpretation and application of typical imaging features of COVID-19. Hammer MM, Raptis CA, Henry TS, Shah A, Bhalla S, Hope MD. Lancet  Respir Med. 2020 Jun;8(6):534-536. doi: 10.1016/S2213-2600(20)30233-2. Epub 2020 May 18.PMID: 32437649

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Development of a long-acting direct-acting antiviral system for hepatitis C virus treatment in swine. Verma M, Chu JN, Salama JAF, Faiz MT, Eweje F, [et al.] Traverso G. Proc Natl Acad Sci U S A . 2020 Jun 2;117(22):11987-11994. doi: 10.1073/pnas.2004746117. Epub 2020 May 18.PMID: 32424082

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How to Obtain a Nasopharyngeal Swab Specimen. Marty FM, Chen K, Verrill KA. N Engl J Med . 2020 May 28;382(22):e76. doi: 10.1056/NEJMvcm2010260. Epub 2020 Apr 17.PMID: 32302471 No abstract available.

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Utility, Appropriateness, and Content of Electronic Consultations Across Medical Subspecialties. Ahmed S, Kelly YP, Behera TR, Zelen MH, Kuye I, [et al.] Mendu ML. Ann Intern Med . 2020 May 19;172(10):641-647. doi: 10.7326/M19-3852. Epub 2020 Apr 14.PMID: 32283548

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Immune-profiling of ZIKV-infected patients identifies a distinct function of plasmacytoid dendritic cells for immune cross-regulation. Sun X, Hua S, Gao C, Blackmer JE, Ouyang Z, [et al.] Yu XG. Nat Commun . 2020 May 15;11(1):2421. doi: 10.1038/s41467-020-16217-5.PMID: 32415086

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Transgender health and haematology-a matter of respect. Connors JM, Middeldorp S. Lancet Haematol . 2020 May;7(5):e367. doi: 10.1016/S2352-3026(20)30107-1. Epub 2020 Mar 30.PMID: 32240620 No abstract available.

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Insulin access and affordability in the USA: anticipating the first interchangeable insulin product. Luo J, Kesselheim AS, Sarpatwari A. Lancet Diabetes Endocrinol . 2020 May;8(5):360-362. doi: 10.1016/S2213-8587(20)30105-4. Epub 2020 Mar 20.PMID: 32203681 No abstract available.

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Estimating lifetime benefits of comprehensive disease-modifying pharmacological therapies in patients with heart failure with reduced ejection fraction: a comparative analysis of three randomised controlled trials. Vaduganathan M, Claggett BL, Jhund PS, Cunningham JW, Pedro Ferreira J, [et al.] Solomon SD. Lancet . 2020 May 21:S0140-6736(20)30748-0. doi: 10.1016/S0140-6736(20)30748-0. Online ahead of print.PMID: 32446323

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Initial Management of Acute Pancreatitis. Chaitoff A, Cifu AS, Niforatos JD. JAMA . 2020 May 7. doi: 10.1001/jama.2020.2177. Online ahead of print.PMID: 32379267 No abstract available.

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Abortion during the Covid-19 Pandemic - Ensuring Access to an Essential Health Service. Bayefsky MJ, Bartz D, Watson KL. N Engl J Med . 2020 May 7;382(19):e47. doi: 10.1056/NEJMp2008006. Epub 2020 Apr 9.PMID: 32272002 No abstract available.

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Whose Autonomy? Stonington SD. JAMA . 2020 May 5;323(17):1686-1687. doi: 10.1001/jama.2020.2873.PMID: 32369137 No abstract available.

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Nasal ACE2 Levels and COVID-19 in Children. Patel AB, Verma A. JAMA . 2020 May 20. doi: 10.1001/jama.2020.8946. Online ahead of print.PMID: 32432681 No abstract available.

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Medicare Part D and Insulin Affordability - The Devil Is in the Details. Dusetzina SB, Huskamp HA, Keohane LM, Keating NL. N Engl J Med . 2020 May 14;382(20):1878-1880. doi: 10.1056/NEJMp2001649. Epub 2020 Apr 1.PMID: 32237673 No abstract available.

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Quantifying genetic effects on disease mediated by assayed gene expression levels. Yao DW, O'Connor LJ, Price AL, Gusev A. Nat Genet . 2020 Jun;52(6):626-633. doi: 10.1038/s41588-020-0625-2. Epub 2020 May 18.PMID: 32424349

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Targeting the ABC transporter ABCB5 sensitizes glioblastoma to temozolomide-induced apoptosis through a cell-cycle checkpoint regulation mechanism. Lee CAA, Banerjee P, Wilson BJ, Wu S, Guo Q, [et al.] Frank NY. J Biol Chem . 2020 May 29;295(22):7774-7788. doi: 10.1074/jbc.RA120.013778. Epub 2020 Apr 20.PMID: 32317280

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COVID-19 preparedness in Malawi: a national facility-based critical care assessment. Sonenthal PD, Masiye J, Kasomekera N, Marsh RH, Wroe EB, [et al.] Rouhani SA. Lancet Glob Health . 2020 May 25:S2214-109X(20)30250-3. doi: 10.1016/S2214-109X(20)30250-3. Online ahead of print.PMID: 32464111

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Crossing Boundaries-Violation or Obligation? Schiff GD. JAMA . 2020 May 5;323(17):1674-1675. doi: 10.1001/jama.2020.2853.PMID: 32369131 No abstract available.

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Genital Powder Use and Ovarian Cancer. Cramer DW. JAMA . 2020 May 26;323(20):2095-2096. doi: 10.1001/jama.2020.3855.PMID: 32453358 No abstract available.

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Renin-Angiotensin-Aldosterone System Inhibitors in Covid-19. Reply. Vaduganathan M, Solomon SD. N Engl J Med . 2020 Jun 11;382(24):e92. doi: 10.1056/NEJMc2013707. Epub 2020 May 19.PMID: 32427431 No abstract available.

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Prescription Fill Patterns for Commonly Used Drugs During the COVID-19 Pandemic in the United States. Vaduganathan M, van Meijgaard J, Mehra MR, Joseph J, O'Donnell CJ, Warraich HJ. JAMA . 2020 May 28:e209184. doi: 10.1001/jama.2020.9184. Online ahead of print.PMID: 32463459 Free PMC article.

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Ondansetron Use in Pregnancy and Congenital Malformations-Reply. Huybrechts KF, Hernandez-Diaz S, Bateman BT. JAMA . 2020 May 26;323(20):2097-2098. doi: 10.1001/jama.2020.5067.PMID: 32453362 No abstract available.

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Need for Transparency and Reliable Evidence in Emergency Use Authorizations for Coronavirus Disease 2019 (COVID-19) Therapies. Zhai MZ, Lye CT, Kesselheim AS. JAMA  Intern Med. 2020 May 19. doi: 10.1001/jamainternmed.2020.2402. Online ahead of print.PMID: 32427277 No abstract available .

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Inequity in Crisis Standards of Care. Cleveland Manchanda E, Couillard C, Sivashanker K. N Engl J Med . 2020 May 13. doi: 10.1056/NEJMp2011359. Online ahead of print.PMID: 32402154 No abstract available.

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Digital Health Equity as a Necessity in the 21st Century Cures Act Era. Rodriguez JA, Clark CR, Bates DW. JAMA . 2020 May 28. doi: 10.1001/jama.2020.7858. Online ahead of print.PMID: 32463421 No abstract available.

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How to Obtain a Nasopharyngeal Swab Specimen. Reply. Marty FM, Chen K, Verrill KA. N Engl J Med . 2020 May 29;382:10.1056/NEJMc2015949#sa5. doi: 10.1056/NEJMc2015949. Online ahead of print.PMID: 32469478 No abstract available.

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**Please visit the new MGB web page for COVID funding opportunities that provides a central database for researchers to view open and competitive funding announcements** *

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