July 2020 The Science Spotlight newsletter features publications from Brigham researchers in high-impact journals and funding updates from the prior month.

In June there were: 57 papers led by Brigham researchers published in top-tier journals 33 tweets about new research 51 awards with $40,530,864 in new grants

ACTRIIA-Fc rebalances activin/GDF versus BMP signaling in pulmonary hypertension Yung LM, Yang P, Joshi S, Augur Z, Kim S [et al.] Yu P Sci Transl Med. 2020;12(543):eaaz5660. doi:10.1126/scitranslmed.aaz5660

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Recommendations for the Conduct and Reporting of Research Involving Flexible Electronic Health Record-Based Interventions. Wright A, McCoy AB, Choudhry NK. Ann Intern Med . 2020 Jun 2;172(11_Supplement):S110-S115. doi: 10.7326/M19-0880.PMID: 32479179

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Genetics of Gene Expression in the Aging Human Brain Reveal TDP-43 Proteinopathy Pathophysiology Yang HS, White CC, Klein HU, Yu L, Gaiteri C, [et al.] De Jager PL. Neuron . 2020 Jun 8:S0896-6273(20)30356-1. doi: 10.1016/j.neuron.2020.05.010. Online ahead of print.PMID: 32526197

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Association Between Healthy Eating Patterns and Risk of Cardiovascular Disease. Shan Z, Li Y, Baden MY, Bhupathiraju SN, Wang DD, [et al.] Hu FB. JAMA  Intern Med. 2020 Jun 15:e202176. doi: 10.1001/jamainternmed.2020.2176. Online ahead of print.PMID: 32539102

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Drug Evaluation during the Covid-19 Pandemic. Rome BN, Avorn J. N Engl J Med . 2020 Jun 11;382(24):2282-2284. doi: 10.1056/NEJMp2009457. Epub 2020 Apr 14.PMID: 32289216

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Prioritising the role of community health workers in the COVID-19 response. Ballard M, Bancroft E, Nesbit J, Johnson A, Holeman I, [et al.] Palazuelos D. BMJ Glob Health . 2020 Jun;5(6):e002550. doi: 10.1136/bmjgh-2020-002550.PMID: 32503889

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The PD-1 Pathway Regulates Development and Function of Memory CD8 +  T Cells following Respiratory Viral Infection. Pauken KE, Godec J, Odorizzi PM, Brown KE, Yates KB, [et al.] Sharpe AH. Cell  Rep. 2020 Jun 30;31(13):107827. doi: 10.1016/j.celrep.2020.107827.PMID: 32610128

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Molecular Pathways of Colon Inflammation Induced by Cancer Immunotherapy. Luoma AM, Suo S, Williams HL, Sharova T, Sullivan K, [et al.] Wucherpfennig KW. Cell . 2020 Jun 25:S0092-8674(20)30688-7. doi: 10.1016/j.cell.2020.06.001. Online ahead of print.PMID: 32603654

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Determination of RNA structural diversity and its role in HIV-1 RNA splicing. Tomezsko PJ, Corbin VDA, Gupta P, Swaminathan H, Glasgow M, [et al.] Rouskin S. Nature . 2020 Jun;582(7812):438-442. doi: 10.1038/s41586-020-2253-5. Epub 2020 May 6.PMID: 32555469

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A positively selected FBN1 missense variant reduces height in Peruvian individuals. Asgari S, Luo Y, Akbari A, Belbin GM, Li X, [et al.] Raychaudhuri S. Nature . 2020 Jun;582(7811):234-239. doi: 10.1038/s41586-020-2302-0. Epub 2020 May 13.PMID: 32499652

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Factors Influencing Physician Practices' Adoption of Behavioral Health Integration in the United States: A Qualitative Study. Malâtre-Lansac A, Engel CC, Xenakis L, Carlasare L, Blake K, [et al.] Friedberg MW. Ann Intern Med . 2020 Jun 2. doi: 10.7326/M20-0132. Online ahead of print.PMID: 32479169

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Development of a long-acting direct-acting antiviral system for hepatitis C virus treatment in swine. Verma M, Chu JN, Salama JAF, Faiz MT, Eweje F, [et al.] Traverso G. Proc Natl Acad Sci U S A . 2020 Jun 2;117(22):11987-11994. doi: 10.1073/pnas.2004746117. Epub 2020 May 18.PMID: 32424082

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Neuropathological Features of Covid-19. Solomon IH, Normandin E, Bhattacharyya S, Mukerji SS, Keller K, [et al.] Sabeti P. N Engl J Med . 2020 Jun 12:NEJMc2019373. doi: 10.1056/NEJMc2019373. Online ahead of print.PMID: 32530583

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Sex Differences in Gene Expression and Regulatory Networks across 29 Human Tissues. Lopes-Ramos CM, Chen CY, Kuijjer ML, Paulson JN, Sonawane AR, [et al.] DeMeo DL. Cell  Rep. 2020 Jun 23;31(12):107795. doi: 10.1016/j.celrep.2020.107795.PMID: 32579922

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Association of Migraine With Aura and Other Risk Factors With Incident Cardiovascular Disease in Women. Kurth T, Rist PM, Ridker PM, Kotler G, Bubes V, Buring JE. JAMA . 2020 Jun 9;323(22):2281-2289. doi: 10.1001/jama.2020.7172.PMID: 32515815 Clinical Trial.

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Large-scale genome-wide association study in a Japanese population identifies novel susceptibility loci across different diseases. Ishigaki K, Akiyama M, Kanai M, Takahashi A, Kawakami E, [et al.] Kamatani Y. Nat Genet . 2020 Jul;52(7):669-679. doi: 10.1038/s41588-020-0640-3. Epub 2020 Jun 8.PMID: 32514122

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Single-molecule regulatory architectures captured by chromatin fiber sequencing. Stergachis AB, Debo BM, Haugen E, Churchman LS, Stamatoyannopoulos JA. Science . 2020 Jun 26;368(6498):1449-1454. doi: 10.1126/science.aaz1646.PMID: 32587015

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Tumor Interferon Signaling Is Regulated by a lncRNA INCR1 Transcribed from the PD-L1 Locus. Mineo M, Lyons SM, Zdioruk M, von Spreckelsen N, Ferrer-Luna R, [et al.] Chiocca EA. Mol Cell . 2020 Jun 18;78(6):1207-1223.e8. doi: 10.1016/j.molcel.2020.05.015. Epub 2020 Jun 5.PMID: 32504554

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Nanoparticle delivery of immunostimulatory oligonucleotides enhances response to checkpoint inhibitor therapeutics. Buss CG, Bhatia SN. Proc Natl Acad Sci U S A . 2020 Jun 16;117(24):13428-13436. doi: 10.1073/pnas.2001569117. Epub 2020 Jun 3.PMID: 32493746

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Myeloid ALX/FPR2 regulates vascularization following tissue injury. Sansbury BE, Li X, Wong B, Patsalos A, Giannakis N, [et al.] Spite M. Proc Natl Acad Sci U S A . 2020 Jun 23;117(25):14354-14364. doi: 10.1073/pnas.1918163117. Epub 2020 Jun 8.PMID: 32513697

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Regulatory approval characteristics of antimicrobial versus non-antimicrobial products, 1984-2018: an evaluation of Food and Drug Administration flexibilities. Darrow JJ, Najafzadeh M, Stefanini K, Kesselheim AS. Lancet  Infect Dis. 2020 Jul;20(7):e159-e164. doi: 10.1016/S1473-3099(20)30197-3. Epub 2020 Jun 2.PMID: 32502431

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Distinct iNKT Cell Populations Use IFNγ or ER Stress-Induced IL-10 to Control Adipose Tissue Homeostasis. LaMarche NM, Kane H, Kohlgruber AC, Dong H, Lynch L, Brenner MB. Cell  Metab. 2020 Jun 5:S1550-4131(20)30256-4. doi: 10.1016/j.cmet.2020.05.017. Online ahead of print.PMID: 32516575

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A rapidly deployable individualized system for augmenting ventilator capacity. Srinivasan SS, Ramadi KB, Vicario F, Gwynne D, Hayward A, [et al.] Traverso G. Sci Transl Med . 2020 Jun 24;12(549):eabb9401. doi: 10.1126/scitranslmed.abb9401. Epub 2020 May 18.PMID: 32424018

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Effect on Patient Safety of a Resident Physician Schedule without 24-Hour Shifts. Landrigan CP, Rahman SA, Sullivan JP, Vittinghoff E, Barger LK, [et al.] Czeisler CA; ROSTERS Study Group. N Engl J Med . 2020 Jun 25;382(26):2514-2523. doi: 10.1056/NEJMoa1900669.PMID: 32579812

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Sex, Gender, and Precision Medicine-Reply. Bartz D, Joffe H, Manson JE. JAMA  Intern Med. 2020 Jun 8. doi: 10.1001/jamainternmed.2020.1620. Online ahead of print.PMID: 32511691

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Challenges in the interpretation and application of typical imaging features of COVID-19. Hammer MM, Raptis CA, Henry TS, Shah A, Bhalla S, Hope MD. Lancet  Respir Med. 2020 Jun;8(6):534-536. doi: 10.1016/S2213-2600(20)30233-2. Epub 2020 May 18.PMID: 32437649

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Getting Value From Electronic Health Records: Research Needed to Improve Practice. Rudin RS, Friedberg MW, Shekelle P, Shah N, Bates DW. Ann Intern Med . 2020 Jun 2;172(11_Supplement):S130-S136. doi: 10.7326/M19-0878.PMID: 32479182

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Avoidable Hospitalizations And Observation Stays: Shifts In Racial Disparities. Figueroa JF, Burke LG, Horneffer KE, Zheng J, John Orav E, Jha AK. Health Aff  (Millwood). 2020 Jun;39(6):1065-1071. doi: 10.1377/hlthaff.2019.01019.PMID: 32479235

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Multifaceted deregulation of gene expression and protein synthesis with age. Anisimova AS, Meerson MB, Gerashchenko MV, Kulakovskiy IV, Dmitriev SE, Gladyshev VN. Proc Natl Acad Sci U S A . 2020 Jul 7;117(27):15581-15590. doi: 10.1073/pnas.2001788117. Epub 2020 Jun 23.PMID: 32576685

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Monogenic and polygenic inheritance become instruments for clonal selection. Loh PR, Genovese G, McCarroll SA. Nature. 2020 Jun 24. doi: 10.1038/s41586-020-2430-6. Online ahead of print.PMID: 32581363

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Estimating The Cost Of Delayed Generic Drug Entry To Medicaid. Dave CV, Sinha MS, Beall RF, Kesselheim AS. Health Aff  (Millwood). 2020 Jun;39(6):1011-1017. doi: 10.1377/hlthaff.2019.00673.PMID: 32479219

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Reporting and Implementing Interventions Involving Machine Learning and Artificial Intelligence. Bates DW, Auerbach A, Schulam P, Wright A, Saria S. Ann Intern Med . 2020 Jun 2;172(11_Supplement):S137-S144. doi: 10.7326/M19-0872.PMID: 32479180

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Intracellular pH controls WNT downstream of glycolysis in amniote embryos. Oginuma M, Harima Y, Tarazona OA, Diaz-Cuadros M, Michaut A, [et al.] Pourquié O. Nature . 2020 Jun 24. doi: 10.1038/s41586-020-2428-0. Online ahead of print.PMID: 32581357

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Quantifying genetic effects on disease mediated by assayed gene expression levels. Yao DW, O'Connor LJ, Price AL, Gusev A. Nat Genet . 2020 Jun;52(6):626-633. doi: 10.1038/s41588-020-0625-2. Epub 2020 May 18.PMID: 32424349

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Small-Molecule Control of Super-Mendelian Inheritance in Gene Drives. López Del Amo V, Leger BS, Cox KJ, Gill S, Bishop AL, [et al.] Choudhary A. Cell  Rep. 2020 Jun 30;31(13):107841. doi: 10.1016/j.celrep.2020.107841.PMID: 32610142

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The protein kinase Akt acts as a coat adaptor in endocytic recycling. Hsu JW, Bai M, Li K, Yang JS, Chu N, [et al.] Li J, Hsu VW. Nat Cell Biol . 2020 Jun 15. doi: 10.1038/s41556-020-0530-z. Online ahead of print.PMID: 32541877

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Notch signalling drives synovial fibroblast identity and arthritis pathology. Wei K, Korsunsky I, Marshall JL, Gao A, [et al.] Raychaudhuri S, Brenner MB. Nature . 2020 Jun;582(7811):259-264. doi: 10.1038/s41586-020-2222-z. Epub 2020 Apr 22.PMID: 32499639

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Introduction: Improvement and Measurement in the Era of Electronic Health Records. Auerbach A, Bates DW. Ann Intern Med . 2020 Jun 2;172(11_Supplement):S69-S72. doi: 10.7326/M19-0870.PMID: 32479178 No abstract available.

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Paying for Medicaid - State Budgets and the Case for Expansion in the Time of Coronavirus. Gruber J, Sommers BD. N Engl J Med . 2020 Jun 11;382(24):2280-2282. doi: 10.1056/NEJMp2007124. Epub 2020 Mar 31.PMID: 32233337

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Author Correction: Merkel cell polyomavirus activates LSD1-mediated blockade of non-canonical BAF to regulate transformation and tumorigenesis. Park DE, Cheng J, McGrath JP, Lim MY, Cushman C, [et al.] DeCaprio JA. Nat Cell Biol . 2020 Jun;22(6):752. doi: 10.1038/s41556-020-0533-9

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COVID-19 and the coming epidemic in US immigration detention centres. Meyer JP, Franco-Paredes C, Parmar P, Yasin F, Gartland M. Lancet  Infect Dis. 2020 Jun;20(6):646-648. doi: 10.1016/S1473-3099(20)30295-4. Epub 2020 Apr 15.PMID: 32304631

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Microbiota and Allogeneic Hematopoietic-Cell Transplantation Madan S, Mehra MR. N Engl J Med . 2020 Jun 11;382(24):2378. doi: 10.1056/NEJMc2006694.PMID: 32521144

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Diagnosing and Treating Systemic Racism. Evans MK, Rosenbaum L, Malina D, Morrissey S, Rubin EJ. N Engl J Med . 2020 Jun 10. doi: 10.1056/NEJMe2021693. Online ahead of print.PMID: 32521155

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Making the Call. Stuart JC. N Engl J Med . 2020 Jun 16. doi: 10.1056/NEJMp2014108. Online ahead of print.PMID: 32543794

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The Game Is Afoot. Yozamp N, Hornick JL, Chiodo CP, Miller AL, Loscalzo J. N Engl J Med . 2020 Jun 4;382(23):2249-2255. doi: 10.1056/NEJMcps1913599.PMID: 32492308

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Can Infections Cause Alzheimer Disease? Komaroff AL. JAMA . 2020 Jun 8. doi: 10.1001/jama.2020.4085. Online ahead of print.PMID: 32511670

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Renin-Angiotensin-Aldosterone System Inhibitors in Covid-19. Reply. Vaduganathan M, Solomon SD. N Engl J Med . 2020 Jun 11;382(24):e92. doi: 10.1056/NEJMc2013707. Epub 2020 May 19.PMID: 32427431

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Specialty Drugs - A Distinctly American Phenomenon. Naci H, Kesselheim AS. N Engl J Med . 2020 Jun 4;382(23):2179-2181. doi: 10.1056/NEJMp1909513.PMID: 32492301

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Airborne Spread of SARS-CoV-2 and a Potential Role for Air Disinfection. Nardell EA, Nathavitharana RR. JAMA . 2020 Jun 1. doi: 10.1001/jama.2020.7603. Online ahead of print.PMID: 32478797

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White Coats for Black Lives: The Time Has Come for Action. Stone VE. Ann Intern Med . 2020 Jun 18. doi: 10.7326/M20-4280.

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Community Health Centers and Covid-19 - Time for Congress to Act. Kishore S, Hayden M. N Engl J Med . 2020 Jun 26. doi: 10.1056/NEJMp2020576. Online ahead of print.PMID: 32589372

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COVID-19, nuclear war, and global warming: lessons for our vulnerable world. Muller JE, Nathan DG. Lancet . 2020 Jun 27;395(10242):1967-1968. doi: 10.1016/S0140-6736(20)31379-9. Epub 2020 Jun 12.PMID: 32539935

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Missed Opportunities on Emergency Remdesivir Use. Sarpatwari A, Kaltenboeck A, Kesselheim AS. JAMA . 2020 Jun 24. doi: 10.1001/jama.2020.11932.

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Fall Prevention in Community-Dwelling Older Adults. Reply. Ganz DA, Latham NK. N Engl J Med . 2020 Jun 25;382(26):2581-2582. doi: 10.1056/NEJMc2005662.PMID: 32579831

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Aspirin for Lynch syndrome: a legacy of prevention. Yurgelun MB, Chan AT. Lancet . 2020 Jun 13;395(10240):1817-1818. doi: 10.1016/S0140-6736(20)30973-9.PMID: 32534636

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Challenges of "Return to Work" in an Ongoing Pandemic. Barnes M, Sax PE. N Engl J Med . 2020 Jun 18:NEJMsr2019953. doi: 10.1056/NEJMsr2019953. Online ahead of print.PMID: 32558484

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False Negative Tests for SARS-CoV-2 Infection - Challenges and Implications. Woloshin S, Patel N, Kesselheim AS. N Engl J Med . 2020 Jun 5. doi: 10.1056/NEJMp2015897. Online ahead of print.PMID: 32502334

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Creating Real Change at Academic Medical Centers - How Social Movements Can Be Timely Catalysts. Morse M, Loscalzo J. N Engl J Med. 2020 Jun 10. doi: 10.1056/NEJMp2002502. Online ahead of print.PMID: 32521157

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Case 20-2020: A 7-Year-Old Girl with Severe Psychological Distress after Family Separation. Gartland MG, Hidalgo JA, Danaher FS. N Engl J Med . 2020 Jun 25;382(26):2557-2565. doi: 10.1056/NEJMcpc2002413.PMID: 32579817

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Funding Opportunity Spotlight

Emergency Reagent Replacement Mini-grant RFA Applications Due: August 1, 2020 The BRI and the Office for Research Careers (ORC) are pleased to announce this program to defray the costs of replacing reagents or other supplies lost due to the COVID-19 interruptions to on-site research. These awards are intended for  immediate usage  by investigators purchasing replacement supplies to restart or continue their research, or as reimbursement for those who have already done so. Funds can be requested up to a  limit of $5,000  and will be awarded  weekly on a rolling basis  based on need and demonstrated loss after review by BRI and ORC staff. Applications should be submitted electronically here .  All questions regarding the Mini-grants should be submitted to  BWHORC@partners.org . Submit Application Here

**Please visit the new MGB web page for COVID funding opportunities that provides a central database for researchers to view open and competitive funding announcements** *

Questions, comments, or concerns? Please reach out to our Research Helpline ResearchHelpline@bwh.harvard.edu with any and all of your research related inquiries!