April 2017

The SCMR Translations Committee recently completed translating the JCMR article, CMR inflammatory vasculitis, into Spanish. The article, originally published in 2012, shows how n oninvasive imaging with cardiovascular magnetic resonance has contributed to improved and earlier diagnosis. The Spanish version was translated by Ricardo Obregón, and Lilia M. Sierra-Galán from the committee.
View this document and other translated publications here >>

Christopher Kramer, MD
Stefan Neubauer, FMedSci FRCP

The HCMR study, Novel Predictors of Prognosis in Hypertrophic Cardiomyopathy, is an NHLBI-funded natural history study in 2750 patients with HCM aimed at improving risk prediction using clinical history, CMR findings, biomarkers and genetics. Recruitment began in April of 2014 and we are thrilled to report that recruitment was completed as of April 7, 2017. The unofficial recruitment competition between the 22 North American and 22 European sites came down to the wire, but Europe pulled out a victory by a 1% margin. Primary outcome events are cardiac death, aborted sudden cardiac death, and cardiac transplantation and a number of secondary outcome events are being collected. Follow-up will continue through April of 2018 and hopefully for several years beyond, once additional funding is secured from the NHLBI. We thank the SCMR community for their support of this important study.


Myocardial Perfusion CMR: Optimized Dual Sequence and Reconstruction for Quantification

Quantification of myocardial blood flow requires knowledge of the amount of contrast agent in the myocardial tissue and the arterial input function (AIF) driving the delivery of this contrast agent. Accurate quantification is challenged by the lack of linearity between the measured signal and contrast agent concentration. This work characterizes sources of non-linearity and presents a systematic approach to accurate measurements of contrast agent concentration in both blood and myocardium. Read full article >>

Cardiac MRI vs. PET for the Evaluation of Cardiac Sarcoidosis: Consider MRI First

Appropriately diagnosing and treating cardiac sarcoidosis remains an important goal because cardiac involvement may occur in up to 25% of patients with sarcoidosis, the large majority of whom may not clinically manifest cardiac symptoms. Yet accurately diagnosing cardiac sarcoidosis remains challenging due to limitations of available clinical criteria and the low yield of endomyocardial biopsy. As a result, there is growing interest in the use of noninvasive advanced imaging techniques, such as cardiac magnetic resonance (CMR) and 18F-fluorodeoxyglucose positron emission tomography (FDG-PET), to evaluate patients with suspected or known cardiac sarcoidosis. This viewpoint will summarize the evidence in support of using CMR for the evaluation of cardiac sarcoidosis. Read full article >>

Stress Perfusion CMR in Patients With Known and Suspected CAD

Stress-perfusion cardiac magnetic resonance (CMR) is increasingly used in daily practice for ischemia detection. However, there is insufficient evidence about the ischemia burden that identifies patients who benefit from revascularization versus those with a good prognosis who receive drugs only. This study sought to determine the ischemia threshold and additional prognostic factors that identify patients for safe deferral from revascularizations in a large cohort of all-comer patients with known or suspected coronary artery disease (CAD). Read full article >>

Association Between Mid-Wall Late Gadolinium Enhancement and Sudden Cardiac Death in Patients with Dilated Cardiomyopathy and Mild and Moderate Left Ventricular Systolic Dysfunction

Current guidelines only recommend the use of an implantable cardioverter defibrillator (ICD) in patients with dilated cardiomyopathy (DCM) for the primary prevention of sudden cardiac death (SCD) in those with a left ventricular ejection fraction (LVEF)<35%. However, registries of out-of-hospital cardiac arrests demonstrate that 70-80% of such patients have a LVEF>35%. Patients with a LVEF>35% also have low competing risks of death from non-sudden causes. Therefore, those at high-risk of SCD may gain longevity from successful ICD therapy. We investigated whether late gadolinium enhancement cardiovascular magnetic resonance (LGE-CMR) identified patients with DCM without severe LV systolic dysfunction at high-risk of SCD. Read full article >>

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