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p75ECD as a Biomarker
The p75 neurotrophin receptor extracellular domain (p75ECD) is a fragment shed from the p75 neurotrophin receptor, a protein involved in a literal cornucopia of functions, including its role in cell death, survival, scar formation, energy expenditure, hypoxic response, tissue repair, metabolism, and neurodegeneration.
Research suggests that p75ECD levels in biofluids like urine may be a biomarker for several neurological diseases, particularly Amyotrophic Lateral Sclerosis (ALS). Studies show significantly higher urinary p75ECD levels in ALS patients compared to healthy controls and those with other neurological conditions. p75ECD levels might correlate with disease progression, with higher levels potentially indicating a faster decline. Baseline p75ECD levels might offer prognostic information on patient survival independent of other clinical parameters.
Biosensis' NGFR/p75ECD ELISA Kits are designed to quantify nerve growth factor receptor extracellular domain fragments in urine. Biosensis offers NGFR/p75ECD ELISA kits engineered explicitly for human or mouse samples, and our kits are highly sensitive. With a broad detection range (62.5 - 4,000 pg/mL) and high sensitivity (< 50 pg/mL), they provide accurate insights even at low concentrations. The comprehensive kits include pre-coated strip plates, standards, QC samples, and detailed protocols. Convenient storage at 2-8°C enhances kit longevity.
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