Issue 260

Phase-Transfer Catalysis Delivers

Low-Cost High-Performance Green Chemistry

PTC Tip of the Month

Quat Carboxylate Catalyzes Polycarbodiimide Formation from Diisocyanate

click here for reaction diagram

The preparation of specialty quat carboxylates is described in this month’s PTC Catalyst of the Month. The procedure was reported by the inventors at BASF who used the quat carboxylates to catalyze the reaction of TXMDI diisocyanate to polycarbodiimide.

It is reasonable to assume that quat carboxylates were chosen in order to...

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PTC Reaction of the Month

PTC-Acid Deprotection of Trityl Group

click here for reaction diagram

Some chemists might find it surprising to learn that phase-transfer catalysis has been used for nearly 40 years to transfer inorganic acids to nonpolar organic phases to perform a variety of reactions including addition of hydrogen halides across double bonds, ether cleavage, acid-catalyzed aldol condensations and ... READ MORE

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Contact Marc Halpern to learn how easy PTC Consulting can be to enhance your R&D performance to achieve high-performance low-cost green chemistry in the shortest time THAT YOUR COMPANY NOW NEEDS! READ MORE

PTC Catalyst of the Month

Preparation of Quat Carboxylates in 2 Steps Using Ion Exchange Resin

Specialty quat salts, such as quat carboxylates, can be prepared from common quat salts, such as commercially available quat bromides and chlorides by ion exchange. However, there are several factors that must be optimized to make this work.

Three factors that must be taken into account are (1) the relative affinities of...

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Safety Notice: Before performing any PTC reactions read this important message! Organic chemical reactions are inherently dangerous. Moreover, phase- transfer catalysis may provide rate and other enhancements which can intensify associated hazards. Under no circumstances should anyone perform any procedure on any scale based in whole or in part on any of the contents of this information provided here. You must first thoroughly establish safe operating procedures and perform a full and competent hazardous operations analysis. The hazop analysis must include the participation of qualified technical personal trained in chemical, engineering, safety, industrial hygiene and environmental disciplines and sciences.

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