October 17, 2019
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William R. Huckle, Editor
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Vascular Biology 2019 
Monterey, CA  

September 9-12, 2020
Conrad Hotel Seoul

Vascular Biology 2020
Newport, RI
October 25-29, 2020

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Help Support NAVBO 
Congratulations to our Travel Award Recipients!
NAVBO will present 20 Travel Awards at Vascular Biology 2019
Thanks to support from the National Heart, Lung and Blood Institute, whose funding will support 16 of these awards, and the Society for Developmental Biology and The Company of Biologists (they are supporting two awards each).  The list of awardees is on our web site at http://www.navbo.org/events/vb2019/travawards19.

We will also be providing ten Outstanding Poster Awards, again most of the funds are from the NHLBI, but ACS Pharmacology and Translational Science is supporting two of these awards. 

Of course, we'd like to remind you and once again extend our congratulations to the NAVBO Meritorious Award Recipients:
William Sessa of Yale for the Earl P. Benditt Award
Anne Eichmann
of Yale for the Judah Folkman Award in Vascular Biology  
Springer Junior Investigator Award
Recipient, Bhama Ramkhelawon of NYU

See all meeting details, including the full schedule and the list of programmed abstracts at www.navbo.org/vb2019  
Online registration for VB2019 is open through October 25, 2019. 

2019 Nobel Prize in Physiology or Medicine
2019 Nobel Prize reflects importance of oxygen...or the lack thereof...as a key vascular regulator
Dateline Stockholm: the   Nobel Prize in Physiology or Medicine 2019 has been awarded jointly to William G. Kaelin Jr, Sir Peter J. Ratcliffe and Gregg L. Semenza for, in the words of the Nobel Committee, "...their discoveries of how cells sense and adapt to oxygen availability." The vascular biology community knows the work of these scientists well, as collectively their research has characterized the fundamental molecular mechanisms by which expression of multiple angiogenic agents, notably VEGF-A, can be regulated by tissue oxygen tension. Although Dr. Semenza has not been a NAVBO member, he spoke at the first Biology of Signaling in the Cardiovascular System Workshop in 2008, presenting a talk titled "Regulation of angiogenesis and arteriogenesis by hypoxia-inducible factor 1." Congratulations to Drs. Kaelin, Ratcliffe, and Semenza...and a tip of the hat to vascular biologists worldwide, many NAVBO members among them, whose research has substantiated the importance of tissue oxygenation status as a vital homeostatic parameter.
Upcoming Webinars
NAVBO Continues to Bring You Exciting Webinars 
Mark your calendar for our next webinar featuring
Hyung Chun of Yale School of Medicine.  His presentation is titled, " Endothelial regulation of metabolic homeostasis," and takes place on November 14 at 1:00pm EST.  His presentation will be related to his paper in Science Translational Medicine
Follow this link to register: Register for this meeting  

Our December 19 webinar (also at 1:00pm  EST) will feature Kristy Red-Horse of Stanford  University.  Her presentation is titled, " Coronary blood vessels play multiple roles in cardiac development."   
Follow this link to register:
Register for this webinar 

NAVBO Webinars are free to current NAVBO Members. Non-members can attend for $25 per webinar.   

And don't forget you can watch archived webinars as well - go to  
Promote Your Presentation on the Web Site
Current NAVBO Members Can List Their Upcoming Presentations (Oral or Poster) on our Web Site
Keep members, and all who visit our web site, aware of presentations by NAVBO members.  If you are attending the meeting, be sure to attend your NAVBO colleague's presentation.  If you are also presenting at that meeting, you can attend each other's presentations and offer mutual support! It can also help make you aware when a colleague is in your town so you reach out and arrange an in-person chat. And finally, this listing can also keep you abreast of other relevant meetings and  conferences.

So check out the current listings: http://www.navbo.org/membership/meeting-presentations-by-members and add yours!
There is a form at the bottom of the page for you to add your presentation.
Lab of the Month
The Lab of Monica Hinds

This month we are highlighting the lab of Dr. Monica Hinds, a Professor in the Department of Biomedical Engineering at Oregon Health & Science University. Find out more about Dr. Hinds and her lab at  http://www.navbo.org/membership/members-labs/838-lab102019.  
Spotlight on Trainees
Re-launch of the Keystone Symposia Fellows Program
Keystone Symposia are pleased to announce the re-launch of their new and improved Keystone Symposia Fellows Program as part of the Diversity in Life Science Portfolio (DSLP).

This one-year program provides leadership and career-development training to early-career scientists from under-represented and disadvantaged backgrounds, to promote their successful career advancement.

Fellows will develop the necessary skills to pursue leadership and decision-making roles in academic, industry and government sectors through hands-on immersive experience, by working directly with eminent scientists from their Scientific Advisory Board.

Key programmatic elements are designed to enhance confidence, leadership skills and networking opportunities.  See their website for more details.
Member News
Sanjeeva Metikala , Ph.D., a post-doctoral researcher in the laboratory of long-time NAVBO member Saulius Sumanas at the Cincinnati Children's Hospital Medical Center, shared the happy news that he has been awarded a Postdoctoral Fellowship by the American Heart Association for 2019-2020. Sanjeeva's poster also earned First Prize in the Postdoctoral competition at the 2019 Midwest Zebrafish Meeting, held at the University of Kentucky in June. Congratulations, Dr. Metikala!

Welcome to our Newest Member:
Ren Cai, Shanghai Ninth People's Hospital
Tracy Hookway, Binghamton University
TC Steven Keller, University of Pennsylvania
Ian Williams, Stanford University
Zheng Zhang, Regeneron Pharmaceuticals

If you have news to share with your colleagues, send it to membership@navbo.org
Recent Publications by NAVBO Members

MicroRNA-mediated control of developmental lymphangiogenesis
The post-transcriptional mechanisms contributing to molecular regulation of developmental lymphangiogenesis and lymphatic network assembly are not well understood.  Read more


Tissue factor pathway inhibitor primes monocytes for antiphospholipid antibody-induced thrombosis
Antiphospholipid antibodies (aPLs) with complex lipid and/or protein reactivities cause complement-dependent thrombosis and pregnancy complications.  Read more


Validation of a Miniaturized Permeability Assay Compatible with CRISPR-Mediated Genome-Wide Screen
Scientific Reports
The impermeability of the luminal endothelial cell monolayer is crucial for the normal performance of the vascular and lymphatic systems. A key to this function is the integrity of the monolayer's intercellular junctions.  Read more


Blood-Brain Barrier Dysfunction in a 3D In Vitro Model of Alzheimer's Disease
Advanced Science
Harmful materials in the blood are prevented from entering the healthy brain by a highly selective blood-brain barrier (BBB), and impairment of barrier function has been associated with a variety of neurological diseases.  Read more


Application of Transmural Flow Across In Vitro Microvasculature Enables Direct Sampling of Interstitial Therapeutic Molecule Distribution
In vitro prediction of physiologically relevant transport of therapeutic molecules across the microcirculation represents an intriguing opportunity to predict efficacy in human populations.  Read more


ALDH1A3 Regulations of Matricellular Proteins Promote Vascular Smooth Muscle Cell Proliferation
Vascular smooth muscle cell (VSMC) proliferation promotes intimal hyperplasia (IH) in occluding vascular diseases. Here we identified a positive role of ALDH1A3 (an aldehyde dehydrogenase) in this pro-IH process.  Read more


Copper Transporter ATP7A (Copper-Transporting P-Type ATPase/Menkes ATPase) Limits Vascular Inflammation and Aortic Aneurysm Development: Role of MicroRNA-125b
Arteriosclerosis, Thrombosis, and Vascular Biology
OBJECTIVE: Copper (Cu) is essential micronutrient, and its dysregulation is implicated in aortic aneurysm (AA) development. Read more


Novel Interaction of Antioxidant-1 with TRAF4: Role in Inflammatory Responses in Endothelial Cells
American Journal of Physiology - Cell Physiology
NADPH oxidase (NOX)-derived reactive oxygen species (ROS) and copper (Cu), an essential micronutrient, have been implicated in vascular inflammatory diseases.  Read more

Industry News (from the October 2 issue)
Input sought on recommendations regarding thrombotic thrombocytopenic purpura
The International Society on Thrombosis and Hemostasis (ISTH) seeks comment on draft recommendations for the diagnosis and treatment of thrombotic thrombocytopenic purpura (TTP). A rare blood disorder, TTP is associated with a lack of activity in the ADAMTS13 metalloprotease that normally cleaves von Willebrand factor and modulates thrombosis. In TTP, blood clot formation in small blood vessels can both limit blood flow to critical organs and give rise to platelet deficiency. The ISTH welcomes comments from clinicians, researchers, allied health professionals, policy makers, industry representatives, patients, caregivers, and other members of the public.
How to assess the trustworthiness of scientific publications?
Writing in STAT , National Academy of Sciences President Marcia McNutt and Kathleen Hall Jamieson, Director of the Annenberg Public Policy Center at the University of Pennsylvania examine the diverse factors that lead readers to accept - or question - the trustworthiness of published scientific findings. They note that "Most of us rely on vetted experts, brand names, seals of approval, and other signals of trust to help us decide on matters ranging from how to treat a dental abscess to which automobile is most fuel efficient. The resources needed to distinguish trustworthy scientific findings from those that are biased, irreproducible, or even fabricated are more elusive." McNutt and Jamieson build a case for the use of badges , a form of "microcredentialing," to provide an objective measure of the degree of trustworthiness a particular published study might warrant.

NSF charts academic intellectual property activity across the US
As those of us who work in academic institutions have likely experienced, universities and their associated research-intensive units are increasingly viewed as drivers of economic growth. Success at the creation of patentable new products, processes, and services that originate in the academy partly reflects the resources devoted to institutional patenting offices. The National Science Foundation tracks indicators that relate the number of academic-owned utility patents to the size of the doctoral science and engineering workforce in academia. How does your state stack up? 
Job Postings
Calendar of Events
Oct 27 - 31, 2019
Vascular Biology 2019
Nov. 22, 2019
Boston Angiogenesis Meeting
Sept. 9 - 12, 2020
21st International Vascular Biology Meeting (IVBM 2020)
Oct 25 - 29, 2020
Vascular Biology 2020
Partner Network Advantage on the NAVBO Job Board
Why post your job on NAVBO's career center rather than going directly to the larger job networks?
Pricing on the mass job boards can vary, but to get a job noticed you typically have to sponsor it for $5 - $10 per day, which can add up quickly especially since you also pay for each click the job gets. When you add it all together, you could be spending up to $45 per day on your job posting. But, when posting a job on NAVBO's career center, you simply pay a flat fee! The Premium package includes our Exclusive Extended Partner Network - which means the jobs are broadcast to sites like ZipRecruiter and Jobs2Careers and more for a flat fee.
With special member pricing, you can post a job for as low as $300 with this Partner Network. You never pay for each click, just the flat fee on the NAVBO career center. In addition, the Premium package includes a 60-day job posting making it a great value. The Premium packages also offer features like having your company's logo featured on the career center homepage, having your job appear first in search results, and more.
Post your open position now at www.navbo.org/jobs!
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Part of the updates relate directly to the European Union's new General Data Protection Regulation (GDPR) that went into place May 25.   The GDPR seeks to improve the transparency of data usage and give end users more control over their own data. We believe these changes are important and will be compliant with the GDPR regulations.
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