An Evening Workshop presented by the Knowledge Forum Committee

The Connection Between Down Syndrome and Alzheimer’s Disease: A Research Study 

When: Tuesday, May 30, 2023

Time: 6:30 - 8:00pm

Where: Online via Zoom

Admission Free, Registration Required

Adults with Down syndrome (DS) are at high risk for developing Alzheimer's disease (AD). Virtually all people with DS have neuropathological changes consistent with AD by age 40 years, including deposits of amyloid-beta (Aβ) in diffuse and neuritic plaques, and most will develop clinical symptoms of dementia by their late 60s.

JOIN US as Dr. Annie Cohen introduces the study being conducted on Alzheimer’s Disease and Down Syndrome. Dr. Handen, one of the principal investigators of ABC-DS, will discuss recent findings from this large study of the aging brain in Down Syndrome. Dr. Rafii, Principal Investigator of the Alzheimer’s Clinic Trial Consortium Down Syndrome will discuss findings from the Trial Ready Cohort-Down Syndrome study and the potential for future clinical trials for Alzheimer’s disease therapies in adults with Down Syndrome. We will conclude the forum with a Question & Answer opportunity for deeper understanding.

Note: The Forum is being recorded and posted online for future viewing.

Complete Event Flyer >

The Alzheimer Biomarkers Consortium Down Syndrome (ABC-DS) is a longitudinal study to follow a cohort of adults with Down syndrome over time to identify early biomarkers that may herald the onset of Alzheimer's disease.

Register Here

A Fun Workshop for Our YES21! Young Adults.....



Wednesday, June 14

6:00 - 7:30PM

Penn State University School of Theatre Building, Room 114

Register Here

Inspired by world renowned clown Bill Irwin, our instructor Malena Ramirez has studied physical comedy at the Yale School of Drama. Malena’s classes invite participants of all ages and abilities to have FUN while they discover their inner clown through games and structured improvisation.

  • No previous experience necessary!
  • Participants should wear comfortable clothing and be prepared to move!
  • Registrants will be sent more details on parking and drop off points at the University closer to the event.

Meet Workshop Instructor Malena! Her Website Includes a Video on the Class too! >

YES21! is a program for our young adults ages 18+. It’s all about having fun and socializing. The organized, chaperoned events are structured to create lots of wonderful opportunities for friendships to bloom. Costs associated with the events are covered by the organization. Guest Hosts are being sought to complete the 2023 events calendar! Visit the webpage for detailed information >


Inherent to the mission of the Centre Region Down Syndrome Society (CRDSS) is the goal of providing financial support for people who have Down syndrome so they are able to participate in activities and have appropriate and necessary equipment that improves their lives. Our Edward Scott Zdenek Enrichment Fund is ready to support families this season. All applications are handled with confidentiality. Read more about this program and consider how we support your family.

Program Details >

Challenger Baseball Has Begun!

CRDSS is a Proud Sponsor of the 2023 Season

Challenger is Little's League's adaptive baseball program for individuals with physical and intellectual disabilities. The teams are divided into two groups for play: Little League (ages 4-17) and Senior League (ages 18+)

Cheer Our Players On!

  • Upcoming Games will be played on May 27 & June 3, 17, 24
  • The Senior League plays at 9am; the Littles play at 10:30am
  • Games played at Sichler Field behind Mt Nittany Middle School

The Community Outreach Committee is bringing our new families together!

Meyer Dairy, State College

3:00 - 4:30PM

Free Event, No Registration

Are you new and looking to meet some other families? If you joined our community in the last year or so and want to make some deeper connections this fun meet-up is for you!

Event Flyer >


2nd Annual

Summer Carnival

Sunday, July 9, 2023

2:00 - 4:30PM

Spring Creek Park,

State College

The Social Committee is planning some amazing summer fun for our community again! Get ready to join us for Games-a-Plenty, Face Painting, a Photo Booth, Parachute Fun, an Ice Cream Bar, Balloons, Dancing, and More!

Seeking Volunteers >

Register Here

Thank You CRDSS Sponsors

Your Annual Support Makes an Impact!

Boyles Insurance ~ Christine Bouley, Coldwell Banker Town & Country ~ Collegiate Pride

Dave's Mask Making ~ Geisinger ~ Ian Smith Painting ~ Jersey Mike's ~ Keystone Payroll ~ Lotsa Laffs

Dr. Marla Moon & Heimer, Fiore, Turco Eye Care ~ Northwest Bank ~ Pediatric Dental Care

Reliance Bank ~ RE/MAX Centre Realty ~ Restek ~ SAS Geospatial LLC ~ The Sign Factory

Skills of Central Pennsylvania ~ Steinbacher, Goodall & Yurchak ~ Strawberry Fields ~ Truist Bank

Details on how to join these supporters >

Support CRDSS Now!

Centre Region Down Syndrome Society is a vibrant, hands-on organization

that provides individuals who have Down syndrome and their families

the tools, resources, and support necessary to participate in, contribute to,

and achieve personal health and fulfillment.

Centre Region Down Syndrome Society

Lauren Smith, Executive Director