MCAAP Immunization Initiative Update
April 2022
National Infant Immunization Week
April 24 - April 30, 2022
#ivax2protect #NIIW
Urge families to stay on track
with well visits and vaccines!

National Infant Immunization Week (NIIW) is April 24 – 30, 2022. Each year, NIIW highlights the positive impact of vaccination on the lives of infants and children — and it’s a priority once again this year to ensure that children stay on track for routine checkups and vaccinations following disruptions from the COVID-19 pandemic.

On-time vaccination is critical to help provide protection against potentially life-threatening diseases. According to CDC research, parents consistently identify healthcare professionals as their most trusted source of health and immunization information. Research also shows that many parents make vaccine decisions before their babies are even born.

During NIIW, the Immunization Initiative encourages you to remind parents and pregnant women about the importance of on-time infant and childhood immunization. Please reach out to any patients who may have missed or delayed their routine well child visits and vaccinations — and encourage them to schedule these important appointments.

Check out the Resource Spotlight section of this newsletter for resources the can you utilize to support immunization during NIIW and beyond.

Thank you for all that you do to protect Massachusetts' children and adolescents against vaccine-preventable diseases!
COVID-19 Vaccines Update

Moderna Files for Authorization of Its COVID-19 Vaccine in Young Children Six Months to Under Six Years of Age

Today (April 28), Moderna announced that it has submitted a request for emergency use authorization (EUA) for its COVID-19 vaccine (mRNA-1273) in children 6 months to under 2 years and 2 years to under 6 years of age to the U.S. Food and Drug Administration and that similar requests are underway with international regulatory authorities. The requests are based on a 25 μg two-dose primary series of mRNA-1273.

The EUA submission for children ages 6 months to under 6 years will be complete next week. Moderna also is currently studying booster doses for all pediatric cohorts.

Massachusetts Weekly COVID-19 Vaccination Report

The MDPH's Weekly COVID-19 Vaccination Report, April 19, 2022, notes that 56% of Massachusetts children aged 5-11, 86% of children aged 12-15, and 85% of children aged 16-19 have received at least one dose of COVID-19 vaccine. The report details COVID-19 vaccination by county as well.

See the Resource Spotlight section of this newsletter for COVID-19 vaccination resources.
Vaccination Coverage with Selected
Vaccines and Exemption Rates Among Children in Kindergarten -
United States, 2020–21 School Year

Key report points:
  • National vaccination coverage among kindergarten children getting their required vaccines during the 2020–2021 school year dropped from 95% to below 94%. This amounts to at least 35,000 more children across the United States entering kindergarten without documentation of complete vaccination against common diseases. 
  • About 400,000 fewer children entered kindergarten than expected based on jurisdictions reporting enrollment data for both years. Those children, too, might not be up to date on their routine vaccinations, further evidence of how pandemic-related disruptions to health care and education could have lingering consequences for school-age children.
  • While coverage dropped in some areas, routine vaccination coverage remains high and ground lost during the COVID-19 pandemic is being re-gained.
  • The national exemption rate (for any exemption) was 2.2%. Massachusetts' exemption rate (for any exemption) was 1.1%, a decrease of -0.2% from the 2019-2020 school year.
  • Massachusetts vaccination coverage among kindergartners remains high (see report Table).
  • This report does serve as a reminder that with most schools back to in-person learning, it’s important that providers, schools, and immunization programs continue efforts to follow up with students who are not fully vaccinated to maintain the high level of coverage necessary to protect children, families, and communities against vaccine-preventable diseases.
CDC Issues Health Alert Network (HAN) Advisory - Recommendations for Adenovirus Testing and Reporting
of Children with Acute Hepatitis of Unknown Etiology

On April 21, the Centers for Disease Control and Prevention (CDC) issued a Health Alert Network (HAN) Health Advisory, "Recommendations for Adenovirus Testing and Reporting of Children with Acute Hepatitis of Unknown Etiology." CDC issued the HAN Health Advisory to notify clinicians and public health authorities of a cluster of children identified with hepatitis and adenovirus infection.

In November 2021, clinicians at a large children’s hospital in Alabama notified CDC of five pediatric patients with significant liver injury, including three with acute liver failure, who also tested positive for adenovirus. All children were previously healthy. None had COVID-19. Case-finding efforts at this hospital identified four additional pediatric patients with hepatitis and adenovirus infection for a total of nine patients admitted from October 2021 through February 2022. A possible association between pediatric hepatitis and adenovirus infection is currently under investigation.

The Health Advisory serves to notify US clinicians who may encounter pediatric patients with hepatitis of unknown etiology to consider adenovirus testing and to elicit reporting of such cases to state public health authorities and to CDC. Nucleic acid amplification testing (NAAT, e.g. PCR) is preferred for adenovirus detection and may be performed on respiratory specimens, stool or rectal swabs, or blood.

Additional resources:
2022 Immunization Updates

The Massachusetts Department of Public Health’s (MDPH) Immunization Division presents free updates on immunization-related topics for health care professionals every spring. MDPH is pleased to announce the 2022 Immunization Updates:

Tuesday, May 24, 2022, 12:00-1:00 PM ET
Massachusetts Immunization Information System (MIIS)

Thursday, May 26, 2022, 12:00-1:00 PM ET
Immunization Schedule Updates

Thursday, June 2, 2022, 12:00-1:00 PM ET
Vaccine Confidence with Dr. Noel Brewer

Wednesday, June 8, 2022, 12:00-1:00 PM ET
Vaccines for Children (VFC) Compliance Training/Vaccine Storage & Handling

Tuesday, June 14, 2022, 12:00-1:00 PM
Epidemiology of Vaccine-Preventable Diseases in Massachusetts

Registration for the updates will open soon. The updates will be held via webinar (no in-person sessions). The updates are free of charge; pre-registration is required. Additional details will be posted as they become available here.
Resource Spotlight

National Infant Immunization Week (NIIW)
Centers for Disease Control and Prevention
American Academy of Pediatrics
  • Communicating with Families and Promoting Vaccine Confidence webpage

COVID-19 Vaccines
Centers for Disease Control and Prevention
  • Interim Clinical Considerations for Use of COVID-19 Vaccines Currently Approved or Authorized in the United States webpage
  • Clinical Care Considerations for COVID-19 Vaccination webpage
  • COVID-19 Vaccines for Children and Teens webpage
  • COVID-19 Vaccine Administration Errors and Deviations factsheet
Massachusetts Department of Public Health
  • COVID-19 Vaccine webpage
  • COVID-19 Vaccine Equity Initiative webpage
  • COVID-19 Mobile Vaccination Program webpage

Catch-Up on Recommended Childhood Immunizations
Centers for Disease Control and Prevention
  • Catch-up Immunization Schedule for Children and Adolescents Who Start Late or Who Are More than 1 Month Behind, United States, 2022 webpage
  • Resources to Encourage Routine Childhood Vaccinations webpage
  • Childhood Vaccination Communication Toolkit for Clinicians
  • You Call the Shots: Vaccinating Adolescents handout

MDPH COVID-19 and Influenza Updates and Bulletins
Provider Education and Meetings

Friday, April 29, 2022, 12:00-1:00 PM
How You Can Become A Vaccine Champion: Strategies to Improve Vaccine Confidence in COVID-19 Vaccines
This virtual meeting will provide evidence-based strategies, including motivational interviewing, to help you improve your COVID-19 vaccine conversations with families with young children. 
Simultaneous interpretation in Spanish and Portuguese will be offered. The meeting is free and all are welcome. Click here for more information and to register for the meeting. Please note: CME/CEU credit will not be offered for this meeting.

May and June 2022
2022 Immunization Updates
See the article above for the 2022 Immunization Updates schedule and topics.

Tuesday, May 4, 2022, 3:00-4:00 PM
Indiana Immunization Coalition
Effective Intercultural Communication
This webinar will offer strategies for communicating respectfully with individuals from various cultural backgrounds. Daniel Griffith, JD, Director of Conflict Resolution and Dialogue Programs at Indiana University-Purdue University Indianapolis (IUPUI) will present. Registration is free and CME-CEU credit will be offered. Click here for more information and to register.

Tuesday, May 10, 2022, 3:30 PM - 7:30 PM
MCAAP Annual Meeting
Every Pediatrician is a School Physician - Lessons Learned from the Pandemic
The meeting will be held at Massachusetts Medical Society, Waltham, MA. CME-CEU credt will be offered. Click here for more information and to register.

Monday, June 28, 2022, 6:30 PM
MCAAP Immunization Initiative Advisory Committee Meeting
This meeting will be held virtually. If you would like to attend the meeting or have questions, please contact Cynthia McReynolds (

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