|
Outcomes in Subsequent Pregnancies of Individuals With Opioid Use Disorder Treated in Multidisciplinary Clinic in Prior Pregnancy (J Addict Med) - Untreated opioid misuse in pregnancy is associated with adverse outcomes. Limited information is available on maternal and perinatal outcomes in subsequent pregnancies for individuals initiated on medication for opioid use disorder (MOUD) in a prior pregnancy.
Methods: Historical cohort study including individuals with opioid use disorder with ≥2 pregnancies between 2013 and 2020, received care in our colocated multidisciplinary clinic for >1 pregnancy, and delivered at our institution. Primary outcome was rate of preconception MOUD. Secondary outcomes included rate of neonatal opioid withdrawal syndrome requiring pharmacologic treatment and length of hospital stay.
Conclusions: Participation in multidisciplinary obstetric and opioid use disorder program increases rate of MOUD in subsequent pregnancy with decrease in illicit drug use.
Delivery timing for the opioid exposed infant (Am J Obstet Gynecol MFM) - The prevalence of opioid use disorder and medication assisted treatment in pregnancy is increasing. Compared to term infants, preterm infants have a lower incidence of neonatal opioid withdrawal syndrome (NOWS). It is unknown whether early term delivery, compared to full or late term, decreases the risk of NOWS.
Objective: To compare neonatal outcomes among opioid-exposed infants born in the early, full and late-term periods.
Results: There were no significant differences in the primary composite outcome, incidence of NOWS, or other secondary outcomes (except birthweight) between neonates born in the early, full or late term periods.
Conclusion: Although neonatal morbidity was frequent among opioid-exposed neonates, the incidence and severity of NOWS or other neonatal outcomes were not different between neonates delivered in the early, full and late term periods, suggesting that opioid-exposed infants may not benefit from early term delivery.
| 
