The IUPHAR and its Clinical and Translational Section has been in active collaboration with the Spanish Society of Clinical Pharmacology and the Argentine Association of Experimental Pharmacology (AAFE) to organize a Clinical Pharmacology Course divided into 3 parts. There were Latin American/IUPHAR Clinical Pharmacology Courses on November 2, 9 and 16 from 3:00pm – 6:00pm (CET). In general, the increasing complexity of clinical drug development has become evident in recent years. Currently, clinical research with drugs or medical devices faces many challenges such as the repositioning of marketed drugs for new indications or the evaluation of new therapies that include biologics or gene modifying agents, which often implies a redefinition of traditional endpoints in efficacy and safety from a perspective of precision medicine.

There have been several publications from NC-IUPHAR in the British Journal of Pharmacology in 2022, some of which were initiated from the twice-yearly meetings of the Nomenclature and Standards Committee (see below). These twice-yearly meetings (in spring and fall) continue to take place as virtual meetings, although it is anticipated that the spring 2023 meeting will allow attendees from within Europe to gather in Paris for discussions. As always, a central focus of these meetings is the database at GuidetoPharmacology.org and the provision of evidence-based content. Beyond these meetings, a current focus of NC-IUPHAR is a systematic analysis of the Family A orphan GPCR, with a view to identifying provisional putative endogenous ligands and reviewing evidence for deorphanizations.