What is already known about this topic?
After the 2022 global mpox outbreak, which primarily affected gay and bisexual men who have sex with men (GBMSM), U.S. cases declined, but low-level transmission continued. Local outbreaks have raised concern about mpox reemergence, including previously unsuspected cases among non-GBMSM.
What is added by this report?
During June–December 2023, among 196 patients aged ≥3 months evaluated at 13 U.S. emergency departments for an mpox-compatible rash irrespective of epidemiologic risk factors, three (1.5%) mpox cases were identified, all among unvaccinated GBMSM who had engaged in sex with one or more partners they met through smartphone dating applications.
What are the implications for public health practice?
Clinicians should remain vigilant for monkeypox virus infections, particularly among GBMSM, and educate patients about the importance of risk reduction and JYNNEOS vaccination.
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