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UAB Obesity Study: Call For Participants
UAB has been designated a Clinical Center site for this groundbreaking study: The Discovery of Risk Factors for Type 2 Diabetes in Youth Consortium (DISCOVERY), funded by the NIH/NIDDK. This multi-center cooperative agreement aims to enroll a racially/ethnically diverse cohort of 3,600 early pubertal youth at high risk for developing Type 2 Diabetes (T2D).
Drs. Barbara Gower (Nutrition Sciences) and Ambika Ashraf (Pediatric Endocrinology) are tasked with recruiting 240 children living within a 2-hour drive of Birmingham. This presents a unique opportunity for your patients to participate in a study that not only seeks to advance understanding of T2D in youth but also offers regular health evaluations during the twice-yearly study visits.
DISCOVERY seeks to extensively phenotype participants aged 9-14 years as they transition through puberty, with an average follow-up of approximately 2.5 years. The study's primary goal is to characterize the decline in pathophysiological processes, including insulin sensitivity and beta-cell function, which lead to youth-onset T2D. By identifying predictive factors for T2D, we hope to enhance future screening and intervention strategies for children at the highest risk of disease development.
Recruitment will begin in May 2024. They are looking for young participants who meet the following eligibility criteria:
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Overweight or obese with BMI ≥85th percentile
- Age 9-13 years for girls, 10-14 years for boys
- Tanner Stage 2 or 3, or Tanner Stage 4 (without initiation of menses for Tanner 4 girls)
- Elevated HbA1c 5.5-6.4% (diagnosed type 2 diabetes is an exclusion)
In addition, potential participants must meet at least one of the following criteria:
- Family history of T2D in 1st or 2nd degree relative
- Personal exposure to gestational diabetes mellitus (GDM)
- HbA1c >5.7%
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Severe obesity (BMI >99th percentile)
- Personal history of intrauterine growth retardation (IUGR), small for gestational age (SGA), or low birth weight
For further details or to discuss potential referrals, please do not hesitate to reach out. You can contact: Dr. Barbara Gower at bgower@uab.edu Dr. Ambika Ashraf at aashraf@uabmc.edu
We believe your role as a primary care provider is pivotal in identifying potential participants who could greatly benefit from this study. Your keen insights into your patients' health histories and your trusted relationship with their families position you uniquely to recommend participation in DISCOVERY.
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