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Vimentin plays a crucial role in neural development, injury, and disease. It orchestrates cell migration and supports neurite outgrowth and axonal guidance. It also influences neural plasticity and cellular interactions with the extracellular matrix. Vimentin is a biomarker for diagnosing and monitoring neurodegenerative diseases. Its breakdown products can indicate brain injury severity, and increased levels correlate with disease progression in Alzheimer’s and multiple sclerosis. Biosensis offers research vimentin antibodies to facilitate vimentin research that will help contribute to our understanding of its roles in both healthy an diseased neurological conditions.
Title figure: View of mixed neuron/glial cultures stained with Chicken polyclonal antibody to Vimentin C-1409-50 (green) and Rabbit polyclonal antibody to Glial Fibrillary Acidic Protein R-1374-50 (red). Vimentin is expressed alone in fibroblastic and endothelial cells, which are the flattened cells in the middle of the image that appear green. Astrocytes may express primarily Glial Fibrillary Acidic Protein (GFAP), or GFAP and vimentin, and so appear red (GFAP only) or golden yellow (GFAP and Vimentin). In cells expressing GFAP and vimentin, the two proteins assemble to produce heteropolymer filaments.
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