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April 2024

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Dear Mesulam Center Community,


Aging deserves a more upbeat public image — it must be more widely recognized that there is more to aging than memory loss and dementia. The Mesulam Center for Cognitive Neurology and Alzheimer's Disease initiated the Northwestern University SuperAging Program (NUSAP) 25 years ago to show that the preservation of memory into the 80’s and beyond does happen and that a long life does not necessarily lead to Alzheimer’s disease. The more we understand about SuperAging the more plausible it becomes to uncover the corresponding lifestyle and biological factors.   


This year, we celebrate a quarter century of SuperAging research at Northwestern. We coined the term “SuperAging” in the 1990s after encountering older research participants with no evidence of the “normal” cognitive decline presumed to be inherent to aging. As we built NUSAP, we developed a specific definition of this cognitive aging trajectory—persons 80 years and above with memory performance that is on par with persons in their 50s and 60s. This impressive group of older adults support the existence of many possible aging trajectories, not all of which conform to the long-held expectation of inevitable decline in late life. At the Mesulam Center, we have enrolled and followed SuperAgers longitudinally for over 20 years and have uncovered many incredible findings about SuperAgers during this time. 


We are immensely grateful to all of our SuperAging participants for generously donating their time and wisdom year after year. SuperAging research is ongoing at the Mesulam Center. Based on our many years of experience, we have adapted our study procedures so there is space for new, innovative research questions. We look forward to continuing to work together to expand our understanding of the unique brain features of SuperAgers. 


Warm Regards,

Robert Vassar, PhD, Marsel Mesulam, MD, and Sandra Weintraub, PhD

Learn More About SuperAging at Northwestern

[8 minute read]

We recently talked to Mesulam Center researchers, those of whom are involved in primary progressive aphasia (PPA) research, about a unique gift many of our research participants have left behind at the Center — their artwork.


Discover the extraordinary journey of individuals living with PPA in our latest feature article and view selected artwork. Uncover how art becomes a profound means of communication and expression amidst language loss, leaving a lasting legacy at the Mesulam Center and beyond.

Read Article
View Art Gallery

Featured Event

Music Movement & Community

1st and 3rd Wednesday of the month,

10:30 AM - 12:00 PM


Lorenzo's House presents Music Movement & Community, a free, in-person interactive experience where music and expression ignite joy. This is an inclusive and stimulating learning environment of personal connection and fun for families living with younger-onset dementia.


April Sessions:

Wednesdays, April 3 and April 17 at Bright Star Church Sanctuary


Questions can be sent to mmc@lorenzoshouse.org.

Learn More and Register

Upcoming Events

South Loop Memory Cafés: April in Paris

The South Loop Village Memory Cafés are free in-person and virtual monthly social gathering for persons living with dementia and their family, friends, and care partners. View upcoming virtual and in-person meeting dates.


In-Person: Thursday, April 11, 1–2 PM

Virtual: Tuesday, April 23, 2–3 PM

30th Annual Alzheimer Day

Friday, May 3, 9:00 AM – 2:30 PM


Join us for the 30th Annual Alzheimer Day, taking place in-person on Friday, May 3 in the Feinberg Pavilion Conference Center. Northwestern Alzheimer Day was established to showcase Alzheimer’s-related dementia and aging research conducted throughout Northwestern and to bring this information to the community. Registration is at capacity, but you may sign up for our wait list here.

Senior Job and Wellness Resource Extravaganza

Monday, April 15, 11:00 AM – 3:00 PM

Join Alderman Lamont J. Robinson for a Senior Job and Wellness Resource Extravaganza at the King Community Resource Center. Congresswoman Robin Kelly will be in attendance, in addition to various exhibitors, including the Mesulam Cetner. Medical Resources will be providing pressure checks and vaccines. Learn more here.

Release the Silence Conference

Saturday, April 27, 10:00 AM – 2:00 PM

Join the Alzheimer's Association Illinois Chapter for the second annual African American Conference, Release the Silence: RACE into Action. During the conference, attendees will get to hear about the latest treatments, learn how to pay for care, and have the opportunity to share their voices in breakout sessions with leaders in the industry. 


Learn more and register.

Featured Publication

Frontotemporal lobar degeneration caused by the tau protein (FTLD-tau) is a neurodegenerative disease identified postmortem, leading to various dementia syndromes. This study explores the impact of Pick's disease (PiD), a subtype of FTLD-tau, on primary progressive aphasia (PPA) and the behavioral variant of frontotemporal dementia (bvFTD). Both syndromes can stem from PiD, affecting language and personality, respectively.


The research aimed to understand the distribution of PiD pathology in different brain regions, establishing connections between disease burden, location, and clinical symptoms. Results revealed that PiD pathology aligned with primary clinical symptoms, with bvFTD showing greater PiD burden in behavior-related regions and PPA demonstrating higher PiD burden in language regions. Surprisingly, the hippocampus, vital for memory, exhibited severe PiD burden, posing intriguing questions about vulnerability to PiD. Overall, this study sheds light on the underlying mechanisms of dementia syndromes associated with PiD.


Authors: Allegra Kawles, Rachel Keszycki, Grace Minogue, Antonia Zouridakis, Ivan Ayala, Nathan Gill, Alyssa Macomber, Vivienne Lubbat, Christina Coventry, Emily Rogalski, Sandra Weintraub, Qinwen Mao, Margaret E Flanagan, Hui Zhang, Rudolph Castellani, Eileen H Bigio, M-Marsel Mesulam, Changiz Geula, Tamar Gefen

Published: Acta Neuropathologica Communications, February 22, 2024

Read the Full Publication

Want to learn more about this and other recent publications from the Mesulam Center? Click here to view all recent publication.

Recent News

Wendy Williams' progressive aphasia, frontotemporal dementia diagnosis

[5 minute watch]

The news of Wendy Williams' dementia-linked diagnoses is an important reminder that the conditions are often missed initially by medical providers, according to Dr. Sandra Weintraub, a clinician and neuropsychologist at Northwestern University, who joined CBS News with a look at the medical effects.

Making Dementia ‘Just a Memory’

[7 minute read]

Robert Vassar, PhD, director of the Mesulam Center, shares his journey from groundbreaking discoveries in molecular genetics to leading the charge against Alzheimer's. With FDA-approved treatments and cutting-edge research, his goal is simple — to make dementia just a memory.

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