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CASE STUDY: PORCUPINE w/URI AND SEVERE DERMATOPHYTOSIS

Case Presentation: "Stinky" - adult male, intact North American Porcupine, presented with upper respiratory infection secondary to severe dermatophytosis.


History: Stinky was brought to a wildlife rehabilitator in Poultney, Vermont, in December of 2023 after being found with severe dermatosis presenting as hair/quill loss and heavy crusting primarily around the face.


The rehabilitator treated for external parasites initially, with only partial improvement. In mid-March, the patient developed a respiratory infection that did not resolve after multiple antibiotic trials (initiated by the rehabber). The patient presented to BEVS’ Exotics Department on March 4, 2024, for worsening respiratory infection.


Stinky was quiet, alert, and responsive on examination and was found to have moderate respiratory effort, stertorous breathing, purulent nasal discharge, significant mucus and white discharge in the oral cavity (assumed to be purulent material), and dermatosis, especially on the face and ventrally. He was anesthetized with isoflurane for closer examination and diagnostics.

"Stinky", an adult male North American porcupine, presented for respiratory disease and suspected mange.

In-House Diagnostics

> Radiographs:

  • Chest: Mild to moderate bronchial pattern. No significant pathogenic changes.
  • Abdomen/musculoskeletal: WNL

> Skin Scrape:

  • Negative for external parasites 

> Intray Dermatophyte Culture (in-house):

  • Suspect Positive” for dermatophytosis – color change and colony growth but colonies were not the typical white.


External Lab Diagnostics

  • Midog (next-generation sequencing): Deep Nasal Swab
  • Trichophyton Banhamiea-concentricum (32.27%)
  • Corynebacterium stationis (26.94%)
  • Staphylococcus epidermis (13.02%)
  • Candida albicans (4.14%)
  • Corynebacterium pseudogenitalium-tuberculostearicum (2.5%)


*Other bacterial and fungal findings deemed not clinically relevant* 


The bacteria were all generally considered normal flora. Interestingly, only the Trichophyton species, an atypical dermatophyte, would be considered a pathogen.


  • UNH Dermatophyte Testing
  • Positive Isolation of Trichophyton sp. of both dermatophyte test medium and microscopic evaluation.
  • UNH Adenovirus Isolation: Pending

"Stinky", after being anesthetized and evaluated by Dr. Adair and exotics tech Molly.

Treatments: Based on clinical findings, Stinky was treated with nebulized gentamycin/saline solution in the hospital. Immediate improvement of respiratory effort and noise was appreciated. Topical Selamectin was applied to ensure complete treatment for external parasites. 


The patient was discharged to the rehabilitator to continue gentamycin nebulization and oral doxycycline pending external lab results.


Upon receiving lab results indicating a fungal component to the upper respiratory infection, the patient was started on Terbinafine in addition to the antibiotic treatments. It was not until the terbinafine was started that significant improvement and, eventually resolution, was noted.


Conclusions/Diagnosis: Stinky suffered from severe dermatophytosis resulting in an upper respiratory infection with significant fungal involvement, in addition to the more common skin issues. While the Trichophyton DNA isolated from Stinky’s deep nasal swab could have been a contaminate from more external areas, the volume of trichophyton DNA recovered compared to other bacterial fungal organisms, and the fact that resolution was noted only after the terbinafine was added, both seem to support it as a primary nasal pathogen. 


A differential diagnosis of Adenovirus is pending based on a collaborative effort with Dr. David Needle, a veterinary pathologist with the University of New Hampshire studying emerging and zoonotic wildlife diseases.


Follow-up: Stinky improved greatly with home treatments, continued to eat well, and became increasingly active. Upon completing nebulization treatments, he was transitioned to an outdoor enclosure to finish oral antibiotics and antifungals.


Stinky has now fully recovered from both dermatophytosis and upper respiratory infection. He has been released back into the wild.

If you would like to refer a patient to our Exotics Department, please call us at 802.863.BEVS (2387). To help expedite the referral process, please fill out our Patient Referral Form online or visit our Referring Veterinary Portal. We look forward to working with you!

Burlington Emergency and Veterinary Specialists

1417 Marshall Avenue, Williston, VT 05495 | 802.863.2387 | bevsvt.com

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