December 21, 2023

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It’s the integration of two powerful new platforms. It’s seeing what’s invisible with a Graph-of-Thoughts (GoT) combined with full reproducibility and traceability. Linthaal is a multi-agents AI Open Source library, taking LLMs as reasoning engines and leveraging Retrieval Augmented Generation (RAG) for Life Science. T2R2™ is the flagship of LLAAMA to automate decentralized data driven decisions in the pursuit of precision medicine.

BioPharmGuy

Happy Holidays everyone! Christmas being on Monday means our Thursdays together shouldn't be too affected. That's the only gift I need this time of year.


Andy

Got called Andy over email again this week. It’s by far the most common wrong name I get. In fact, I can’t think of another wrong name at all.


The best is when someone initially calls me Adam, then later that same day, I become Andy.


Microwave Buttons

How many buttons does a microwave need?


1) "Add 30" with auto start. (In its proper form, you can keep pressing it to add 30 more seconds.)


That's it.


You don't even need a clear button. Every microwave should automatically clear the residual time after it's been opened and closed.


And yet my microwave has "auto defrost", "express defrost", "soften", "melt", "9, "auto cook", "8", "potato" and many more. Pointless.


-BPG


Companies Added & Removed

18 companies added, 14 removed this week.


Best New Name:

Cadenza Bio


Worst New Name:

Deep Apple Therapeutics


You Will Be Missed:

Indiana Lysis Technologies


Excel summary file of adds/removals available free on our downloads page.

Industry

Chestnut Roast – Ysopia

We held on to this one all year only to have the rug pulled last week. The website is down, so we can't prove to you that Sandy Claus is real.


Or can we?


Internet Archive to the rescue! Yes, Sandy Claus is real and she is (or at least was) the CSO at Ysopia Bioscience.


So, what are they working on over at Ysopia? Just the therapeutic potential of the bacteria known as CHRISTensenella.


Blue Water Vaccines -> Blue Water Biotech -> Onconetix

Onconetix is the latest name for Blue Water Vaccines/Biotech


It made sense to shift the name from Vaccines to Biotech - opened up their therapeutic world. But they had second thoughts on that openness, because now it’s all oncology with the extremely boring Onconetix, which sounds like a million other biotech names. 


How many companies do we list that start with Onc? 114.


Even better, there's already been an Onconetics Pharmaceuticals (RIP)


3/10


T-rex Battle

Why settle for one biotech named after Tyrannosaurus Rex when we can have two?


Because there can be only one, that's why. Showdown time!


Participants: TRex Bio vs T-Rex Biopharma


Logo

TRex Bio: stylized dinosaur eye

T-Rex Biopharma: standard t-rex skull

Winner: TRex Bio


Color Scheme

TRex Bio: light and dark greens

T-Rex Biopharma: blue

Winner: TRex Bio


Business

TRex Bio: Immunology therapies

T-Rex Biopharma: staffing

Winner: TRex Bio


It's a wipeout - TRex Bio is the winner. Though once we realized the second was just a misleadingly named staffing company, it kind of defeated the purpose since they're not a biotech company. Ah whatever.


Oh, by the way, you missed out on the chance to buy a T-Rex skull for $20M last year.


Pipeline Therapeutics

One of the most atrocious names in the biz has been retired. Pipeline Therapeutics has moved on to become Contineum Therapeutics


This new one is not the greatest looking name, but man, Pipeline Therapeutics was just useless. Naming their company after a standard drug company website menu item was something to behold.


You think they considered Contact Us Therapeutics or Team Therapeutics before going with Pipeline?


Feudal Funding

BioPharmGuy has suggested this story multiple times to journalists and they have ignored it, so it’s time to let it rip.


If you didn’t know, there has been an explosion of small biotech funding that is being executed by large drug companies, all of which seem to have a venture capital arm these days. 


Owning your future competitors might be just a little anti-competitive, right?


So why is this being ignored by everyone, everywhere as if it’s some irrelevant detail?


Can people really not imagine a scenario where Lilly may snuff out a portfolio company’s drug in its clinical infancy in what is nothing more than veiled monopoly preservation? 


Let’s not be naïve – that’s at least partially why these companies are investing, no matter what they say.


What brought this to a head for us was the announcement of a funding round by EvolveImmune Therapeutics that was bankrolled by Pfizer, Takeda and BMS


Did you know there are 43 companies in the BioPharmGuy directory partially funded by Eli Lilly. 43!! 


Another 25 for Pfizer, 21 for Novartis, 14 for Bayer, etc.


Large companies partnering with smaller ones has long been a common way for big companies to effectively outsource their drug development. But when those happen, they're usually the only large company connected to the small one and have an ownership stake in the drugs.


How would that work if multiple competing drug companies co-invest in a small one? It's murky to say the least.


That older partnering method of funding is still going on. Fierce recently published survey results and found about half the small companies are relying on big companies to fund them through these tough times.


Any biotech journalist out there who wants some data to help research this topic, let us know.


Stupid Apparatus

Thanks to a company changing its name, then changing it back, we have this stupid sounding, yet accurate, entry for a company called Biostage in our deep directory: 


“Renamed Harvard Apparatus Regenerative Technology, Jul 2023; fka Harvard Apparatus Regenerative Technology”


StimWave Goodbye

You can’t do any business in America these days! Now the government has indicted a medical device CEO for simply implanting totally nonfunctional medical devices in patients.


Come on! Free market!!!


But seriously, it doesn’t get more egregious than this right here. The Florida-based company is alleged to have knowingly installed nonfunctional devices in patients.


This isn’t like those electrotherapy devices that gullible people buy to sit around and “heal their cells” or some crap. This involved actual surgery. What the hell.


Hopefully this CEO can say hey to Elizabeth Holmes when she meets her in Federal Prison.


Florida: Still the medical fraud capital of America.


Google Sees All

When you build a website from a template, it’s a good idea to delete the prefilled pages you are not going to use, lest some cheeky copy make it into the Google search results.


Pragma Bio, did not prune the bushes and thus you have this Christmasy filler item from an episode of Doctor Who about Santa aka Jeff. Oops.


Oh Ship

Sometimes metaphors can be taken too far. If you liken your company to a ship, that's ok. If you're working on drugs and want to say that ship is moving "forward in the blue ocean of health care", acceptable.


But if you then refer to something else as a ship, you lose us. From Hasten Biopharmaceutical's CEO message:


"Hasten Biopharma is like a ship flying forward. We will strive to move forward in the blue ocean of health care by the ship of doctor-patient service, taking human health as the shore, innovation as the paddle, forging ahead as the sail."


Paddles and sails? Amusing they decided to model their organization after a Carthaginian warship.

Health & Science

Santa Boogie

Last week, SNL ran a sketch about the newly approved sickle cell anemia cure, Casgevy. In it, a sickle cell sufferer trades away access to the cure in office Yankee Swap. Was pretty funny.


But as is their animus, advocates immediately voiced concern about this comedy sketch. They claim it contained errors and perpetuated stereotypes about sickle cell sufferers.


The “error” that was pounced upon was when a white character who does not have the disease ends up with the cure and someone suggests maybe he could give it to a family member of his who has sickle cell. He states: “doubt it, my whole family’s white”. 


While it's possible for Caucasians to have it, only about 1-in-55,000 suffer from sickle cell disease. So, someone with only white relatives should doubt that any relatives have it.


The “stereotype” was that sickle cell sufferers make bad decisions about their health.


Count us in the camp of people who never heard of that nor thought about it for one second until this 'advocacy' group just suggested it. It's a genetic disease - that's as unrelated to the patients' decisions as possible.


And then, a sickle cell sufferer was quoted as saying the skit reminded her of kids teasing her for yellowing skin when she was young. 


Go watch the sketch and explain that one. There is no allusion to anything of the sort – the joke is simply an amazing cure to a disease is available and the characters instead opted for a silly dancing statue. 


You'd think these people/groups could look past such minor issues considering the disease can now be CURED for many people. Shouldn't it be a euphoric 'Mission Accomplished' era?


Down with the Outrage-Industrial Complex!

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