A: Immunofluorescence staining of neuronal cilia in rat neuron-glial cultures using

anti-ACIII polyclonal antibody (R-1687-100; red). Co-stained with neuronal alpha-II spectrin (M-1575-100; green) and DNA (blue).

B: Immunohistochemistry of mouse brain sections using anti-ACIII polyclonal antibody (R-1687-100; green) antibody reveals specific cilia labeling near pyramidal neurons in the CA1 hippocampus region, while other brain areas remain unlabeled. Co-stained with anti-Fox3/NeuN (M-377-100; red) and DAPI for cell nuclei (blue).

C: Western blot analysis of rat olfactory epithelium (Lane 1) and frontal cortex (Lane 2) using anti-ACIII polyclonal antibody (R-1687-100). It detects a prominent 200 kDa protein band in cilia-rich olfactory epithelium, while the frontal cortex, with fewer cilia and lighter glycosylation, shows a less prominent 160 kDa band.

Path to a Pain-Free Future!

Recent research suggests that peripheral ACIII plays a crucial role in regulating pain signals and the pain-relieving effects of opioids that interact with the κ-opioid receptor. Therefore, further research on this protein could help us better understand how to manage pain and develop new treatments for opioid addiction. Explore the advantages of detecting ACIII with our antibody.

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